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Biosynthesis
Thromboxane A2 promotes interleukin-6 biosynthesis
October 25th, 2005
Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. According to recent research published in the journal Molecular Pharmacology, "1321N1 human astrocytoma cells express thromboxane A2 (TXA2 ) receptors (TP). However, physiological consequences of TXA2 signaling in glial cells remain unclear." "Herein," explained Y. Obara and colleagues, Tohoku University, "we show that TXA2 promotes interleukin-6 (IL-6) biosynthesis in glial cells. A TP agonist,...
Source: cancer weekly (2005-10-25)
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