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Brain Cancer



Sporadic brain tumors require sustained Hh-Gli signaling for sustained survival



October 25th, 2005

Sporadic brain tumors require sustained Hedgehog-Gli signaling for sustained survival.

According to a recent report published in the Journal of Neurobiology, "The Hedgehog-Gli (Hh-Gli) signaling pathway is essential for numerous events during the development of many animal cell types and organs.

"In particular, it controls neural cell precursor proliferation in dorsal brain structures and regulates the number of neural stem cells in distinct embryonic, perinatal, and adult niches, such as the developing neocortex, the subventricular zone of the lateral ventricle of the forebrain, and the hippocampus."

"We have proposed that...


Source: cancer weekly (2005-10-25)

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