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Breast Cancer
TP53 mutations associated with specific genomic imbalances
October 25th, 2005
In breast carcinomas, mutant TP53 genes are generally accompanied by a set of specific genomic imbalances. "TP53 mutations play an important role in the development of several cancers and are present in 20%-40% of all breast carcinomas, contributing to increased genomic instability," pathologists in Norway explained. "In order to address the relationship of mutated TP53 to genomic complexity," K. Kleivi and colleagues at the Norwegian Radium Hospital "analyzed 61 breast carcinomas for TP53 mutations, and compared mutation status with the pattern of genomic imbalances as assessed by comparative genomic hybridization...
Source: cancer weekly (2005-10-25)
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