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Adenovirus
National Institutes of Health publishes research in adenovirus
December 18th, 2007
Data detailed in 'Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus' have been presented. According to recent research from the United States, "Oncolytic adenoviruses as a treatment for cancer have demonstrated limited clinical activity. Contributing to this may be the relevance of preclinical animal models used to study these agents." "Syngeneic mouse tumor models are generally non-permissive for adenoviral replication, whereas human tumor xenograft models exhibit attenuated immune responses to the vector. The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for...
Source: cancer weekly (2007-12-18)
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