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Cancer Gene Therapy



Southeast University describes research in cancer gene therapy



December 18th, 2007

Fresh data on cancer gene therapy are presented in the report 'DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.' According to recent research from Nanjing, People's Republic of China, "Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality in the world; however, the molecular mechanisms leading to hepatocyte transformation, especially in epigenetic mechanisms (such as DNA methylation) are still poorly understood. DNA methyltransferase 1 (DNMT1) is the predominant maintenance methyltransferase gene required to maintain DNA methylation patterns in...


Source: cancer weekly (2007-12-18)

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