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Gene Therapy
Researchers at Institute of Child Health target gene therapy
December 18th, 2007
Researchers detail in 'Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector,' new data in gene therapy. "The expression of genes specifically in B cells is of great interest in both experimental immunology as well as in future clinical gene therapy. We have constructed a novel enhanced B cell-specific promoter (Igk-E) consisting of an immunoglobulin kappa (Igk) minimal promoter combined with an intronic enhancer sequence and a 3' enhancer sequence from Ig genes," researchers in London, the United Kingdom report. "The Igk-E promoter was cloned into a lentiviral vector and used to control...
Source: cancer weekly (2007-12-18)
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