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Breast Cancer
Research reports on breast cancer from D.J. Dabbs and colleagues provide new insights
December 18th, 2007
"Pleomorphic lobular carcinoma of the breast is a high nuclear grade variant of lobular carcinoma. E-cadherin, a tumor-invasion suppressor gene, codes for a transmembrane protein that functions in intercellular adhesion," scientists writing in the journal Applied Immunohistochemistry & Molecular Morphology report. "The E-cadherin protein internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the E-cadherin complex to the actin cytoskeleton of the cell. The E-cadherin gene is routinely mutated in lobular neoplasia. This study examines the morphomolecular spectrum of the components of the E-cadherin-catenin complex in lobular neoplasia. Fifteen...
Source: cancer weekly (2007-12-18)
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