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Howard Hughes Medical Institute
53BP1 links DNA damage response to Ig heavy chain class-switch recombination
June 23rd, 2004
DNA damage-response activity has been linked to Ig heavy chain class-switch recombination through the 53BP1 protein. "The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs)," scientists in the United States explained. In a recent study, J.P. Manis and colleagues at the Howard Hughes Medical Institute in Boston examined "potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes." "Although 53BP1 was dispensable for V(D)J recombination and somatic hypermutation (SHM), the processes by which immunoglobulin (Ig) variable...
Source: elder law weekly (2004-06-23)
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