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Inha University
Evans Blue acts as protein tyrosine phosphatase inhibitor
June 23rd, 2004
Evans Blue and other dyes act as protein tyrosine phosphatase inhibitors. According to a study from South Korea, "Commonly used dyes including Evans Blue and Trypan Blue were examined for their inhibitory activities against protein tyrosine phosphatases (PTPases), all of them showed inhibition of PTPases with different potencies. "Of the 13 dyes tested, four exhibited IC50 value of less than 10 micromolar, Evans Blue lowest IC50 of 1.3 micromolar against PTP1B." "Care must be taken in the use of dyes for clinical or biochemical experiments to avoid unwanted side effects," stated Suja Shrestha and colleagues...
Source: elder law weekly (2004-06-23)
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