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Chinese University of Hong Kong
The loss of RASSF1A expression propels nasopharyngeal cancer proliferation
June 23rd, 2004
The loss of RASSF1A expression propels nasopharyngeal cancer proliferation. According to recent research published in the International Journal of Cancer, "deletion on the short arm of chromosome 3 is one of the most important genetic abnormalities in the tumorigenesis of nasopharyngeal carcinoma (NPC). Both physical mapping and functional studies have targeted an NPC-related tumor suppressor gene(s) to chromosome 3p21.3." "We have reported recently that RASSFIA gene, located on a 120-kb minimal deletion region on 3p21.3, was frequently inactivated by promoter hypermethylation in NPC. We further confirmed that RASSFIA is the critical target...
Source: elder law weekly (2004-06-23)
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