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National Taiwan University
Hepatitis C virus NS3 and NS4A interactions modulate RNA unwinding activity
June 23rd, 2004
Hepatitis C virus NS3 and NS4A interactions modulate RNA unwinding activity. According to published research from Taiwan, "to determine whether the two domains of hepatitis C Virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins- the NS3H protein, containing only the helicase domain, the full-length NS3 protein, and the NS3-NS4A complex." "The results revealed that NS3 displayed the weakest RNA helicase activity, not because it had lower ATPase or RNA binding activity than did NS3H or NS3-NS4A, but because it...
Source: elder law weekly (2004-06-23)
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