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Hannover Medical School
Neuropeptides do not induce mediator release in isolated intestinal mast cells
June 23rd, 2004
Neuropeptides do not induce mediator release in isolated intestinal mast cells. "Neuropeptides such as substance P (SP) and related peptides are supposed to act as mast cell agonists, and thus as mediators of neuroimmune interactions. The data supporting this hypothesis were obtained mostly from rodent experiments. Here, we studied for the first time the effect of SP and other peptides on mediator release in human intestinal mast cells, either unpurified or enriched to 85-99% purity," scientists writing in the journal Neurogastroenterology and Motility report. "We found that SP at 0.1-100 mcM L-1, or other peptides including neurokinin A and...
Source: elder law weekly (2004-06-23)
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