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Harvard University
Leptin induces patterns of immediate early gene expression in the brain
June 23rd, 2004
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. "Ciliary neurotrophic factor (CNTF) and leptin decrease food intake and body weight. Lipopolysaccharide (LPS) is a potent exogenous pyrogen and produces anorexia via cytokine production. CNTF-, leptin-, and LPS-induced cytokines all act on type I cytokine receptors. However, it is not known if these cytokines engage similar central nervous system (CNS) pathways to exert their effects. To assess mechanisms by which these cytokines act, we examined the patterns of immediate early gene expression (SOCS-3, c-fos, and tis-11) in the brain following intravenous...
Source: elder law weekly (2004-06-23)
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