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King's College London
Parkinson disease mutations affect axonal transport in cultured neurons
June 23rd, 2004
Parkinson disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons. "Alpha-synuclein is a major protein constituent of Lewy bodies and mutations in alpha-synuclein cause familial autosomal dominant Parkinson disease. One explanation for the formation of perikaryal and neuritic aggregates of alpha-synuclein, which is a presynaptic protein, is that the mutations disrupt alpha-synuclein transport and lead to its proximal accumulation. "We found that mutant forms of alpha-synuclein, either associated with Parkinson disease (A30P or A53T) or mimicking defined serine, but not tyrosine, phosphorylation states exhibit reduced...
Source: elder law weekly (2004-06-23)
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