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Huddinge University Hospital
Anti-Gal IgG potentiates NK cell migration via endothelial cell activation
June 23rd, 2004
Anti-Gal IgG potentiates NK cell migration via endothelial cell activation. According to published research from Sweden, "Xenoreactive antibodies (Ab) are important for the development of acute vascular rejection (AVR) of xenografts characterized by monocytes, natural killer (NK) cells and neutrophils infiltrating the graft. The mechanisms by which anti-galactosealpha 1,3galactose (alpha-Gal) IgG influence NK cell migration across porcine aortic endothelium (PAEC) were investigated." "NK cell migration across PAEC increased in the presence of anti-a-Gal IgG. Anti-a-Gal IgG exposure activated PAEC as shown by an increased expression of CD62E and...
Source: elder law weekly (2004-06-23)
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