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2009 JUL 6 ... its effects on AMPK phosphorylation and TNF-alpha-induced I kappa B-alpha degradation. AICAR, a direct AMPK activator, had inhibitory effects on TNF-alpha-induced IL-6 production, ...
2009 JUL 6 ... cardiac function in failing canine hearts. Interestingly, another AMPK activator (AICAR) had effects equivalent to those of metformin, suggesting the primary role of AMPK ...
2009 JUL 13 ... were then exposed to gAd or 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) for 6 h. Stimulation with gAd decreased pyruvate dehydrogenase kinase 4 (PDK4) gene ...
2009 NOV 23 ... We observed that activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) significantly reduced ROS levels induced by palmitic acid in human aortic endothelial ...
2009 JUL 6 ... also regulates apoptosis. 5'-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) is a cell-permeable AMPK activator," researchers in the United States report. ...
2009 SEP 21 ... relaxation and increased the levels of GTPCH I and BH4. The administration of AICAR, an AMPK activator, or adenoviral overexpression of a constitutively active mutant of ...
2009 SEP 7 ... with an activator for AMPK, 5-amino-imidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). Inhibitors for signal transducers, Compound C, H-89, and MDL-12,330A, restored the ...
2009 JUL 13 ... is activated by exercise and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)," investigators in Denmark report. "Early pre-conditioning involves AMPK ...
2009 JUL 27 ... report. "Adiponectin, 5-aminoimidazole-4-carboxamide-1-4-ribofuranoside (AICAR) and metformin activate the AMP-kinase that exerts anti-inflammatory effects, and the ...
2009 JUL 6 ... phosphorylation of its target acetyl CoA carboxylase. AMPK activators metformin and AICAR partly prevented the cell cycle block, oxidative stress and apoptosis induced by ...
2009 JUL 20 ... EC, Sherwin RS, McCrimmon RJ. Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 ...
2009 NOV 1 ... protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), a Rho-associated protein kinase inhibitor, fasudil hydrochrolide, as well as HMG-CoA ...
2009 OCT 12 ... of EGFR signaling in determining response in vitro and in vivo. The AMPK-agonist AICAR, and activated AMPK adenovirus, inhibited mTOR signaling and blocked the growth of ...
2009 AUG 31 ... the presence of the AMPK agonist 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR, 0-500 mu mol/l). AMPK and acetyl-CoA carboxylase (ACC) phosphorylation, basal and ...
2009 NOV 23 ... cells were incubated with metformin or 5-aminoimidizole-4-carboxamide ribonucleoside (AICAR). Lipoprotein lipase activity, LPL protein expression, and LPL messenger RNA (mRNA) ...
2009 SEP 29 ... cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) by the AMPK activator, AICAR." "C75, an activator of CPT1 and FAO, stimulated meiotic resumption in ...
2009 AUG 18 ... the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5'-phosphoribosyl-5-amino-4-imidazole carboxamide)," researchers in Bordeaux, France ...
2009 OCT 19 ... produce imidazole glycerol phosphate (IGP) and 5-aminoimidazole-4-carboxamide ribotide (AICAR). Binding of PRFAR and IGP stimulates glutaminase activity in the HisH enzyme over 5,000 ...
2009 NOV 1 ... CRY1 and severely disrupting peripheral clocks. In contrast, treating mice with AICAR, a synthetic drug that directly activates AMPK, reset the clock in cultured cells as ...
