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2009 NOV 2 ... to recent research from the United States, "The discovery of azidothymidine's (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the ...
2009 AUG 31 ... Yet the regular use of those drugs - such as zidovudine (also known as azidothymidine or AZT), protease inhibitors, and highly active antiretroviral therapy (HAART) involving ...
2009 JUN 1 ... betulonic acid, TMC120 (dapivirine), PMPA, and 3'-azido-3'-deoxythymidine (AZT or zidovudine), which, when combined, were found to block infection in human cells ...
Subject: New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
2009 SEP 21 ... intracellular metabolites of 4'-Ed4T was qualitatively similar to that of zidovudine (AZT) but not to that of d4T, while after drug removal it showed more persistent anti-HIV ...
2009 OCT 19 ... patients. Twelve HIV-1 infected patients, with stably suppressed HIV-1 viral load using AZT/3TC/abacavir for >= 6 months, added NVP to their current antiretroviral regimen," ...
2009 SEP 28 ... glycol) carbonate prodrugs of the antiretroviral drug zidovudine (azidothymidine, AZT) in an attempt to enhance the physicochemical properties for transdermal delivery, which ...
2009 NOV 16 ... We have hypothesized that the cardiac mitochondrial toxicity of the nucleoside analogue AZT (3'-azido-3'-deoxythymidine; known as zidovudine) is caused by inhibition of thymidine ...
2009 OCT 19 ... (Tyr(268)) displayed similar kinetic parameters. Because 3'-azido-3'-deoxythymidine (AZT), one of the most current nucleotide reverse transcriptase inhibitors prescribed in ...
2009 JUN 1 ... virus (HIV) dideoxynucleosides (ddNs). Because most anti-HIV ddNs (e. g., zidovudine, AZT) exhibit clinical mitochondrial toxicity, we investigated whether hENT3 facilitates ...
2009 JUL 6 ... for symptom relief and in cases of persistent or escalating symptoms zidovudine (AZT) is substituted for D4T Leg pain or numbness was reported in 1173 patients (35%). ...
2009 JUL 13 ... to define mitochondrial oxidative stress and cardiomyopathy (CM) induced by zidovudine (AZT), an antiretroviral used to treat HIV/AIDS. Genetically engineered mice either depleted ...
2009 AUG 10 ... (NHMECs) exposed to the antiretroviral drug zidovudine (3'-azido-3'-deoxythymidine, AZT)," scientists in the United States report. "Centrosomal ...
2009 JUL 28 ... reversed phase LC method was developed and validated to analyze the in vitro release of AZT from microemulsions. A mobile phase of acetonitrile:water (15:85) was used," scientists ...
2009 OCT 19 ... to recent research from the United States, "Zidovudine (3'-azido-3'-deoxythymidine; AZT), which is currently used in the treatment of acquired immunodeficiency syndrome, has ...
2009 AUG 17 ... in Jiangsu possibly via two independent introductions from Fujian. Fourth, two AZT resistance mutations in the RT gene were detected within patient JSWX045, who did not ...
2009 OCT 19 ... 1 (HIV-1) subtype B reverse transcriptase (RT) increase 3'-azido-3'-deoxythymidine (AZT) resistance in the context of thymidine analog mutations (TAMs) by affecting the balance ...
2009 AUG 24 ... of IV-IVE based on human liver microsomal kinetic data, the kinetics of zidovudine (AZT) glucuronidation by HLM were characterized in the absence and presence of BSA and IFABP ...
