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2009 NOV 16 ... not been fully elucidated." "In the present study, we have tested whether alpha(2)-adrenoceptors require specific G alpha isoforms for their function in vivo. In ... G alpha(i) isoforms, G alpha(i1), G alpha(i2), and G alpha(i3), in typical alpha(2)-adrenoceptor-controlled functions. Mice with targeted deletions in the genes encoding G alpha(i1), G ...
2009 OCT 19 ... "The rank-order potency against lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha production by human peripheral blood mononuclear cells was roflumilast (IC50 = 5 nM) ... pica model were confirmed in a second surrogate model of emesis, reversal of alpha(2)-adrenoceptor-mediated anesthesia in the mouse. The rank order of therapeutic indices derived in the ...
2009 SEP 22 ... interaction between endogenous receptors in human embryonic kidney 293 cells in which G alpha(q/11)-coupled muscarinic M-3 receptors facilitate Ca2+ signaling by G alpha(s)-coupled ... channels, particularly inositol (1,4,5)-trisphosphate receptors. However, beta(2)-adrenoceptor-mediated Ca2+ release was independent of measurable increases in phospholipase C ...
Subject: Pharmacology and Experimental Therapeutics
2009 OCT 26 ... According to recent research published in the British Journal of Anaesthesia, "alpha(2)-Adrenoceptor agonists are currently used as primary sedative agents in high ...
2009 SEP 28 ... According to recent research from Kiel, Germany, "Alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein ... mechanisms. We have Studied whether morphine and fentanyl interacted With alpha(2)-adrenoceptor-subtype in mice lacking one individual alpha(2)-adrenoceptor-subtype ...
2009 OCT 19 ... central nervous system (CNS) penetrant, potent, selective, partial agonist at the human alpha 1(A)-adrenoceptor, demonstrating efficacy and selectivity in a range of binding and ...
2009 NOV 9 ... Current study results from the report, 'Increased alpha-1 adrenoceptor expression in pregnant rats with subrenal aortic coarctation,' have been ...
2009 NOV 2 ... "The activity of various 1-(3-(4-arylpiperazin-1-yl)-propyl)-pyrrolidin-2-ones alpha(1)-adrenergic receptors (alpha(1)-ARs) antagonists, was described using the quantitative ... Science (1-(3-(4-Arylpiperazin-1-yl)-propyl)-Pyrrolidin-2-one Derivatives as alpha(1)-Adrenoceptor Antagonists: A QSAR Study. QSAR & Combinatorial Science, 2009;28(9):979-988). ...
2009 NOV 23 ... muscle and induce coronary vasoconstriction in humans. A deletion variant of the human alpha(2B)-adrenoreseptor of glutamic acid residues has been associated with impaired receptor ... Our aim was to study whether an insertion/deletion (I/D) polymorphism in the alpha(2B)-adrenoceptor gene is associated with the risk for sudden cardiac death. This was a prospective ...
2009 NOV 9 ... induced by epinephrine, phenylephrine, or methoxamine can be significantly reduced by alpha(1)-adrenoceptor antagonists (eg, prazosin), alpha 1,alpha 2-adrenoceptor antagonist, ...
2009 SEP 29 ... "Cold-induced vasoconstriction is mediated in part by selective enhancement of local alpha(2C)-adrenoceptor (alpha(2C)-AR) activity. A common insertion-deletion variant in the ...
2009 NOV 9 ... of morphine by 4-fold (from 120 to 480 min), which was reversed by pretreatment with the alpha-2 adrenoceptor inhibitor, yohimbine, and the mu-type opioid receptor antagonist, ...
2009 NOV 1 ... M 55, Ottawa, on K1A 0R6, Canada. Keywords: Egypt, Alexandria, Adrenergic alpha-Agonist, Cardiotonic, Drugs, Endocrinology, Enzyme Research, Estradiol, Estrogen, ... to a study from Alexandria, Egypt, "We previously reported that nicotine impairs P-adrenoceptor-mediated renovascular control in male rats. Here, we investigated the roles of sex and ...
2009 NOV 9 ... agents did not affect the noradrenaline concentration-response curves except for the alpha-adrenoceptor antagonists. These results led to the conclusions that neurogenic ...
2009 NOV 2 ... rings as a function of gestational age; and (ii) the uterotonic and tocolytic actions of alpha- and beta-adrenoceptor stimulation, respectively. The effects of oxytocin in late ...
2009 OCT 12 ... "Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and ...
2009 NOV 9 ... clomipramine, fluoxetine and imipramine (1 nM-10 mc M) on the tension induced by the alpha(1)-adrenoceptor agonist NE (10 mc M) of SV strip preparations were studied using the ...
2009 OCT 5 ... research from Kanazawa, Japan, "The nonselective beta-adrenoceptor and the selective alpha(1)-adrenoceptor blocker carvedilol are widely used in hypertensive and/or cardiac ...
2009 OCT 5 ... alter NA-induced cell death. These effects of NA were mediated, in part, through alpha-adrenoceptor because phenylephrine (100 mu mol/L), like NA, also induced p38 MAPK ...
