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2009 NOV 9 ... "To investigate the possible involvement of the angiotensin system, an angiotensin II receptor antagonist, candesartan cilexetil, or a nonspecific vasodilator, hydralazine hydrochloride, was ...
2009 NOV 23 ... Pharmaceuticals, Drugs, Telmisartan, Nifedipine, Captopril, Atenolol, Losartan, Angiotensin II Receptor Antagonist, Antiarrhythmic, Antihypertensive. This article was prepared by Biotech ...
2009 NOV 16 ... Research findings, 'AngiotensinII activates connective tissue growth factor and induces extracellular matrix changes ... Smad2 phosphorylation. Transient transfection with Smad7, which interferes with receptor-mediated activation of Smad2, diminished Ang II-induced connective tissue growth factor ... Smad overexpression and Smad-dependent gene transcription. The angiotensin type 1 (AT1) antagonist losartan diminished Ang II-induced Smad activation. The blockade of endogenous ...
2009 NOV 9 ... "The centrally mediated cardiovascular regulatory actions of angiotensinII in normal and hypertensive rats include angiotensinII type 1 receptor ... to 50% of the GFP-containing neurons, an effect that was abolished by the AT1R antagonist losartan (1 mu mol/L). Consistently, 9 of 28 GFP/PAG-expressing neurons contained AT1R ...
2009 NOV 9 ... is deposition of amyloid-beta protein (A beta) in the brain. Telmisartan is a unique angiotensinIIreceptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ... mg/kg per day) was administered in drinking water with or without GW9662, a PPAR-gamma antagonist. Cerebral blood flow was evaluated by laser speckle flowmetry. Inflammatory cytokine ...
2009 NOV 2 ... "AngiotensinII is the principle effector molecule of the renin angiotensin system (RAS). It exerts ... cardiovascular and renal system, mainly via interaction with the angiotensin II type-1 receptor (AT1R), which contributes to blood pressure regulation and development of hypertension ... inhibitor enalapril, as well as preventive or therapeutic application of the AT1R antagonist losartan, resulted in a significantly ameliorated course of MOG-EAE. Blockade of AT1R ...
2009 NOV 10 ... PA 19106-3621, USA. Keywords: Germany, Berlin, Angiotensins, Angiotensin, Angiotensin II Receptor Antagonist, Antiarrhythmic, Antihypertensive, Hypertension, Losartan. This article was ...
2009 NOV 9 ... New York, NY 10010-1710, USA. Keywords: Iran, Angiotensins, Angiotensin, Angiotensin II Receptor Antagonist, Antiarrhythmic, Antihypertensive, Biochemical, Blood Pressure, Erythrocytosis, Kidney ...
2009 NOV 9 ... "Connective tissue growth factor (CTGF) plays a critical role in angiotensinII (Ang II)-mediated hypertensive nephropathy. The present study investigated the ... cells lacking the TGF-beta gene, which was blocked by the addition of an Ang II type 1 receptorantagonist (losartan) and inhibitors to extracellular signal-regulated kinase 1/2 ...
2009 NOV 9 ... According to recent research from the United States, "Agonistic autoantibodies to the angiotensinII type I receptor (AT1-AA) and endothelin -1 (ET-1) are suggested to be important links ... pregnant rats infused with AT1-AA and NP rats were treated with an ETA receptor antagonist. MAP was 100 +/- 1 mm Hg in AT1-AA + ETA antagonist-treated rats versus 98 +/- 2 mmHg in ...
2009 NOV 16 ... "The octapeptide hormone angiotensinII (AngII) binds to and activates the human angiotensinII type 1 receptor (hAT(1)) of ... I, II, IV, and V on both receptor forms. The mutants were photolabeled with a neutral antagonist, I-125-[Sar(1),p-benzoyl-L-Phe(8)] AngII, and the resulting complexes were digested with ...
2009 NOV 16 ... to recent research from the United States, "The existence and localization of brain angiotensin receptors is well established. However, questions regarding the endogenous ligand for ... receptor binding studies." "To assess the ability of angiotensin II to bind to the brain AT(1) receptor, radioligand binding studies of rat brain AT(1) ... angiotensin II. Determination of binding kinetics and competition by an AT(1) receptor antagonist was carried out to reveal the identity of the membrane binding sites and to identify the ...
