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2009 NOV 16 ... published in the journal Antimicrobial Agents and Chemotherapy, "Ethambutol (EMB) is an antimycobacterial drug used extensively for the treatment of tuberculosis caused by Mycobacterium ... synthesis of LAM. We show that mutations in EmbCMt that reduce its arabinosyltransferase activity result in increased sensitivity to EMB and the production of smaller LAM species in M. ...
2009 SEP 14 ... nitrogen intermediates. Moreover, IL-10-dependent arginase-1 induction diminished antimycobacterial effector mechanisms in macrophages. Taken together, macrophage-derived IL-10 triggers ... in Mtb-infected macIL-10 transgenic mice. Importantly, arginase-1 gene expression and activity were strikingly enhanced in transgenic mice accompanied by a reduced production of ...
2009 OCT 5 ... of 4-benzylsulfanylpyridine-2-carbohydrazides was synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, non-tuberculous mycobacteria, and ...
2009 MAR 9 ... call and Streptococcus. Furthermore, it has been reported that murine SLPI shows potent antimycobacterial activity," scientists writing in the American Journal of Respiratory and Critical Care ...
2009 APR 20 ... using SUVmax. In addition, 14 patients with PM underwent repeat PET scanning during antimycobacterial therapy, and changes in F-18-FDG uptake were clinically evaluated (6 during treatment ... the usefulness of F-18-FDG PET in the imaging of pulmonary lesions related to disease activity and in monitoring responses to treatment in patients with pulmonary mycobacteriosis ...
2009 JUN 1 ... "We herein describe the synthesis and antimycobacterial activity of a series of 27 different derivatives of 3-benzyl-6-bromo-2-methoxy-quinolines and ...
2009 NOV 2 ... 2-mercaptopropionic acid," investigators in Istanbul, Turkey report. "The antimycobacterial activity of these compounds was determined and several leads with 95-99% inhibition at 6.25 mu ...
2009 APR 27 ... of N-benzylsalicylthioamides was synthesized and the compounds were tested for in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium," ...
2009 FEB 9 ... A report, 'Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids,' is newly published data in ... smegmatis (MC(2)) and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. smegmatis. Among the 48 synthesized compounds, ...
2009 NOV 23 ... autophagosomes in human macrophages in a cathelicidin-dependent manner. Furthermore, the antimycobacterial activity in human macrophages mediated by physiological levels of 1,25D3 required autophagy and ...
2009 JUN 22 ... 1 can be inhibited by sulfonarnides and sulfamates and thus has potential for developing antimycobacterial agents with an alternate mechanism of action," wrote T. Minakuchi and colleagues, ... by the gene Rv 1284 (mtCA 1) of Mycobacterium tuberculosis shows appreciable catalytic activity for CO, hydration, with a k(cat) of 3.9 x 10(5) s(-1) and a k(cat)/K-m of 3.7 x 10(7) ...
2009 FEB 16 ... ATB107 was identified as a potential binding molecule; it was tested, and shown to have antimycobacterial activity in vitro not only against the laboratory strain M. tuberculosis H37Rv, but also against ...
2009 MAR 23 ... using SUVmax. In addition, 14 patients with PM underwent repeat PET scanning during antimycobacterial therapy, and changes in (18)F-FDG uptake were clinically evaluated (6 during treatment ... of 18F-fluorodeoxyglucose positron emission tomography for diagnosing disease activity and monitoring therapeutic response in patients with pulmonary mycobacteriosis,' new ...
2009 JUL 6 ... "Also, it provides clues for rational design of putative CYP121 substrate-based antimycobacterial agents." Belin and colleagues published their study in Proceedings of ... P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity remains unknown." "Here, we show that the cyclodipeptide ...
2009 JUN 29 ... derivatives (3a-p) was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv," investigators in Istanbul, Turkey ...
2009 AUG 10 ... acid synthesis and mycobacterial growth, opening an avenue for the development of novel antimycobacterial agents.." Leger and colleagues published their study in Chemistry & ... of M. tuberculosis polyketide-synthase-associated adenylation enzymes possessing such activity," wrote M. Leger and colleagues. The researchers concluded: "A substrate ...
2009 AUG 24 ... mycobacteria and may help to design improved inhibitors of PknG to be developed as antimycobacterial compounds.." Scherr and colleagues published their study in the Journal of ... macrophage cytosol upon mycobacterial infection, suggesting that PknG might exert its activity by interfering with host signaling cascades, but the mode of action of PknG remains ...
2008 DEC 29 ... Prince of Songkla University.
The researchers concluded: "For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value ...
2008 DEC 22 ... It would serve as a good second-line screen for characterization of compounds showing antimycobacterial activity in a first-line screen," wrote N. Gupta and colleagues.
The researchers ...
2008 DEC 23 ... 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-diones often led to an improvement in the antimycobacterial activity against M. tuberculosis."
Waisser and colleagues published their study ...
