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2009 NOV 23 ... listeriolysin-O (LLO) and a model tumor antigen have been shown to exert strong antitumor activity. The aim of this study is to extend these observations to a self-protein and clinically ...
2009 NOV 29 ... by inhibiting MDM2 in human trials.Keywords: Pediatrics, Anticancer Therapy, Antitumor Activity, Cancer, Hematology, Neuroblastoma, Oncology, Small Molecule Inhibitor, Treatment, ...
2009 NOV 23 ... Nano report."The resulting nanoparticle, HFT-T, is expected to retain the antitumor activity of paclitaxel and specifically target folate receptor (FR)-expressing tumors, thereby ...
2009 NOV 16 ... in Seoul, South Korea report. "However, the molecular basis for the antitumor activity of triterpenoid has yet to be defined. In this study, we show that pristimerin, a ...
2009 NOV 25 ... confirmed that EC0305 is the most favorable conjugate of the group due to its potent antitumor activity [100% cures at 1 mu mol/kg, three times a week (TIW) for 2 weeks] and its favorably low ...
2009 NOV 16 ... colleagues published their study in Lipids (Suppression in Mevalonate Synthesis Mediates Antitumor Effects of Combined Statin and gamma-Tocotrienol Treatment. Lipids, ... "Statins directly inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) activity, while gamma-tocotrienol, an isoform of vitamin E, enhances the degradation and reduces ...
2009 NOV 16 ... B.I. Rini and colleagues, Cleveland Clinic. The researchers concluded: "Antitumor activity was observed across multiple solid tumors. (Clin Cancer Res 2009;15(19):6277-83)." ...
2009 NOV 23 ... "In this paper we analyzed the influence of two mechanistically diverse antitumor agents-cisplatin and methotrexate on the proliferation and cell cycle of two head and ... that adenovirally mediated p53 overexpression at sub-cytotoxic levels enhanced the activity of low doses of cisplatin and methotrexate in HEp-2 and CAL 27 cells through changes in ...
2009 NOV 23 ... DCs matured in the presence of Toxoplasma gondii components induce a potent antitumor response in a mouse model of fibrosarcoma. Bone-marrow derived DCs (BMDCs) were cultured ... site. Tumor growth was monitored, and 2 weeks after DC immunotherapy, the cytotoxic activity and the infiltration of CD8(+) T cells were monitored in different groups. According to ...
2009 NOV 16 ... "An open-label, multicenter, phase 11 study was conducted to define the safety and antitumor activity of the monoclonal antibody SGN-30 in patients with CD30(+) primary cutaneous anaplastic ...
2009 NOV 23 ... Researchers detail in 'The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma,' new data in ovarian cancer. "This ...
2009 NOV 16 ... isozyme-specific CA inhibitors are proposed, given that inhibition of this enzyme shows antitumor activity both in vitro and in vivo." Alterio and colleagues published their study ...
2009 NOV 23 ... may aid the exploration of new therapeutic strategies to potentiate antimicrobial and antitumor immunity. J. Leukoc. Biol. 86: 941-948; 2009." Presicce and colleagues ... Italy, "Defensins are endogenous defense peptides with well-defined antimicrobial activity against a broad spectrum of pathogens including bacteria, fungi, viruses, and parasites. ...
2009 NOV 16 ... IGF-1R has become a focus for cancer drug development." "We examined the antitumor activity of CP-751,871, a human antibody that blocks IGF-1R ligand binding, alone and in ...
2009 NOV 16 ... of TGF-beta receptor I kinase," investigators in Bari, Italy report. "The antitumor activity of LY2109761 was associated with inhibition of molecular pathways involved in ...
2009 NOV 16 ... orally bioavailable mTORC1 and mTORC2 inhibitor that demonstrates pharmacodynamic and antitumor activity in multiple human cancer xenograft models will be presented on Tuesday, November 17, ...
2009 NOV 16 ... ERK inhibitor-induced apoptosis. Treatment with the ERK inhibitor showed marked in vivo antitumor activity in a human DLBCL xenograft model. Our findings establish a functional molecular ...
