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2009 NOV 16 ... Dr Bernard Laffranchi, head of Clinical Research, said: "These indications of antitumor activity, also present in the second phase I study performed in solid tumors in the USA ... Biotechnology Company, Clinical Oncology, Clinical Research, Clinical Trial Research, Drugs, Enzymes, Infectious Disease, Kinase, Lung Neoplasms, Non-Small Cell Lung Cancer, ...
2009 NOV 16 ... cells. In vivo studies showed that the combination of these agents has a significant antitumor activity against HeLa xenograft tumors. Our results suggest that mifepristone can ... be a useful candidate for further evaluation in combination with other antineoplastic drugs in the treatment of cancer, particularly with cisplatin." Jurado and ...
2009 NOV 16 ... flattened, slower-growing phenotype. R04929097 is active following oral dosing. Antitumor activity was shown in 7 of 8 xenografts tested on an intermittent or daily schedule in ... States, Nutley, Enzyme Research, Apoptosis, Cancer, Cell Proliferation, Clinical Trials, Drugs, Enzymes, Oncology, Pharmaceuticals, Pharmacodynamics, Pre-Trials Research, Secretase, ...
2009 NOV 23 ... Nano report."The resulting nanoparticle, HFT-T, is expected to retain the antitumor activity of paclitaxel and specifically target folate receptor (FR)-expressing tumors, ... "Nonspecific distribution of chemotherapeutic drugs (such as paclitaxel) is a major factor contributing to side effects and poor clinical ...
2009 NOV 16 ... structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor activity. The total synthesis of these antitumor agents has enabled the production of ... Keywords: United States, Mobile, Anticancer Therapy, Antitumor Activity, Drugs, Experimental Therapies, Mutagenesis, Pharmaceuticals, Pharmacology, Phosphatase, ...
2009 NOV 16 ... in Seoul, South Korea report. "However, the molecular basis for the antitumor activity of triterpenoid has yet to be defined. In this study, we show that pristimerin, ... Antiinflammatory, Antimalarial, Antitumor Activity, Cervical Cancer, Cervical Carcinoma, Drugs, Malaria, Molecular Pharmacology, Molecular Therapies, Oncology, Pharmaceuticals, ...
2009 NOV 16 ... colleagues published their study in Lipids (Suppression in Mevalonate Synthesis Mediates Antitumor Effects of Combined Statin and gamma-Tocotrienol Treatment. Lipids, ... Carcinoma, Oncology, Women's Health, Reductase, Enzymes, Simvastatin, Pharmaceuticals, Drugs, Therapy, Treatment, Vitamin E, Dietary Supplement, Micronutrient, University of ...
2009 NOV 23 ... "In this paper we analyzed the influence of two mechanistically diverse antitumor agents-cisplatin and methotrexate on the proliferation and cell cycle of two head and ... City:Zagreb, Country:Croatia, Biotechnology, Cisplatin, Clinical Oncology, Cytometry, Drugs, Gene Therapy, Genetics, Genomics, Head and Neck Cancer, Head and Neck Carcinoma, ...
2009 NOV 17 ... intracellular copper homeostasis. hCtr1 is involved in the transport of platinum-based antitumor agents such as cisplatin (CDDP); however, the mechanisms that regulate hCtr1-mediated ... USA. Keywords: United States, Houston, Life Sciences, Pharmacology, Drugs, Pharmaceuticals, Therapy, Treatment, Cisplatin, Copper, Molecular Pharmacology, ...
2009 NOV 16 ... and murine models of melanoma and to investigate the possible mechanisms of synergistic antitumor effects. The effects of reovirus +/- chemotherapy on in vitro cytotoxicity and viral ... Kingdom, Guildford, Cancer, Chemotherapy, Cisplatin, Combination Therapy, Drug Therapy, Drugs, Experimental Design, Melanoma, Oncology, Pharmaceuticals, Reoviridae, Reovirus, ...
2009 NOV 23 ... Researchers detail in 'The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma,' new data in ovarian cancer. ... PTX combinations and may have implications for the design of clinical trials with these drugs." Cesca and colleagues published their study in Neoplasia (The effects of ...
2009 NOV 16 ... isozyme-specific CA inhibitors are proposed, given that inhibition of this enzyme shows antitumor activity both in vitro and in vivo." Alterio and colleagues published ... Anhydrase, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Drugs, Enzymes, Oncology, Pharmaceuticals, Solid Cancers, Solid Carcinomas, Therapy, Tissue ...
2009 NOV 9 ... Republic of China report. "In addition, preliminary evaluation of antitumor activity using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) ... Therapy, Antimetabolite, Antineoplastic, Antitumor Activity, Drug Development, Drugs, Enzyme Inhibitor, Folic Acid Antagonist, Magnetic Resonance, Medicinal Chemistry, ...
2009 NOV 9 ... effect of 5-FU. Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-FU antitumor activity through the activation of PPAR gamma," wrote L.Q. Cao and colleagues. ... Activity, Apoptosis, COX-2 Inhibitors, Chemotherapy, Drug Resistance, Drug Therapy, Drugs, Fibrinolytic Agent, Fluorouracil, Hepatocellular Cancer, Hepatocellular Carcinoma, ...
2009 NOV 16 ... (synthetic dsRNA)." "Immune responses were measured by flow cytometry and antitumor efficacy was evaluated by tumor size and survival. In situ cytotoxicity assays and ... Cyclophosphamide, Cytometry, Drug Development, Drug Resistance, Drug Therapy, Drugs, Experimental Design, HPV, Human Papillomavirus, Immunotherapy, Oncology, ...
2009 NOV 16 ... xenograft and experimental metastasis models showed that Bay11-7082 had significant antitumor effects on ESCC xenografts in nude mice by promoting apoptosis, and inhibiting ... proliferation, but also induced apoptosis and enhanced sensitivity to chemotherapeutic drugs, 5-fluorouracil, and cisplatin. In addition, Bay11-7082 and sulfasalazine suppressed the ...
2009 NOV 16 ... orally bioavailable mTORC1 and mTORC2 inhibitor that demonstrates pharmacodynamic and antitumor activity in multiple human cancer xenograft models will be presented on Tuesday, ... Squibb Company Inc., Carboplatin, Clinical Trial Research, Clinical Trials, Drugs, Enzymes, Erlotinib, Glioma, Kinase, Marketing and Licensing Agreements, Oncology, ...
2009 NOV 16 ... Bcl-2 messenger RNA (mRNA), down-regulates Bcl-2 protein translation and enhances antitumor effects of subtherapeutic chemotherapy doses. Within a phase I trial, we administered ... Clinical Trial Research, Cyclophosphamide, Docetaxel, Drug Resistance, Drug Therapy, Drugs, Gene Therapy, Oncology, Pharmaceuticals, Taxotere, Treatment, Women's Health. ...
