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2009 OCT 26 ... study from Scotland, "Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis." "Despite the inherent limitations of all animal models, several rodent ...
2009 NOV 23 ... proinflammatory cytokine that plays an important role in the pathogenesis of rheumatoid arthritis (P-A). OPN can be cleaved by thrombin, resulting in OPN-R and exposing the cryptic ...
2009 NOV 2 ... "Systemic-onset juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by arthritis and systemic features. Its ... (JIA) is an autoimmune disease characterized by arthritis and systemic features. Its pathogenesis is still largely unknown," scientists in Netherlands report. "It is ...
2009 NOV 23 ... (SNPs) in the 5'-regulatory region of the DNASE2 gene, in patients with rheumatoid arthritis (RA) and healthy controls. A total of 906 patients with RA and 878 healthy controls were ... region of the DNA degrading enzyme DNASE2 with RA implies a role for this enzyme in the pathogenesis of this autoimmune disease." Rossol and colleagues published their study ...
2009 NOV 1 ... with ankylosing spondylitis (AS) differed in protein expression compared to rheumatoid arthritis (RA) and healthy controls (HC). Monocyte protein expression was characterised by 2D gel ... proteomic analyses support the hypothesis that monocytes play an important role in the pathogenesis of AS and RA, and further suggest a specific role in AS for the UPP," wrote C. Wright ...
2009 NOV 23 ... genotype than the CA or the CC genotype was observed in patients with chronic disabling arthritis (5.5% vs 25.0% or 19.2%, respectively)," wrote D.Y. Chen and colleagues, National ... to a study from Taichung, Taiwan, "Interleukin 18 (IL-18) has a central role in the pathogenesis of adult-onset Still's disease (AOSD). We investigated the functional association of ...
2009 NOV 23 ... system seen in SLE patients." Low and colleagues published their study in Arthritis and Rheumatism (C1q Inhibits Immune Complex-Induced Interferon-alpha Production in ... also a typical finding in SLE during flares, emphasizing the involvement of C1q in SLE pathogenesis." "Recent studies have revealed that C1q has a regulatory effect on ...
2009 NOV 2 ... According to recent research from Spain, "Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA, ... The researchers concluded: "Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component ...
2009 NOV 23 ... "It was hypothesised that these variants could influence rheumatoid arthritis (RA) susceptibility and may interact with functional single nucleotide polymorphisms ... pathway and highlight the potential importance of gene-gene interactions in the pathogenesis of RA." Marinou and colleagues published their study in Annals of the ...
2009 NOV 2 ... fibroblasts (SFs) contribute to several aspects of the pathogenesis of rheumatoid arthritis (RA) and have been implicated most prominently in the progressive destruction of ...
2009 NOV 23 ... a major regulator of pivotal proinflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA). Bortezomib inhibits NF-kappa B activation by blocking the degradation of the ...
2009 NOV 4 ... characteristic of OA." Miyaki and colleagues published their study in Arthritis and Rheumatism (MicroRNA-140 Is Expressed in Differentiated Human Articular Chondrocytes ... tissue-specific expression patterns, and changes in their expression may contribute to pathogenesis." "The objectives of this study were to identify miRNA expressed in ...
2009 NOV 2 ... According to recent research published in the journal Arthritis and Rheumatism, "SIRT1 is known to inhibit apoptosis and to promote survival of various ... The researchers concluded: "Further research on SIRT1 might contribute to resolving the pathogenesis of OA." Takayama and colleagues published their study in Arthritis and ...
2009 NOV 2 ... is warranted." Visentini and colleagues published their study in Arthritis and Rheumatism (Regression of Systemic Lupus Erythematosus After Development of an ... suggest, although indirectly, that signaling through TLR-9 and TLR-7 is important in the pathogenesis of human SLE, and indicate that investigation of potential treatment strategies with TLR ...
2009 OCT 19 ... Scientists discuss in 'The role of toll-like receptors in rheumatoid arthritis' new findings in arthritis. According to a study from the United States, "An ... "An increasing body of data supports the role of the innate immune system in the pathogenesis of rheumatoid arthritis (RA). Toll-like receptors (TLRs) are expressed by cells within ...
2009 NOV 23 ... According to recent research from Israel, "Studies have suggested that rheumatoid arthritis (RA) and osteoarthritis (OA) share common characteristics. The highly selective A(3) ... of chondrocytes. CF101 deregulated the NF-kappa B signaling pathway involved in the pathogenesis of OA," wrote S. Baryehuda and colleagues, Can-Fite BioPharma. The ...
2009 NOV 1 ... "In recent years, factors potentially involved in pathogenesis of rheumatoid arthritis have mostly been identified by studying well-defined patient cohorts," scientists in ...
2009 NOV 23 ... chondrocyte senescence." Zushi and colleagues published their study in Arthritis and Rheumatism (Induction of Bovine Articular Chondrocyte Senescence With Oxidized ... The researchers concluded: "Oxidized LDL may play an important role in the pathogenesis of osteoarthritis by inducing chondrocyte senescence." Zushi and ...
