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2009 NOV 23 ... cancer cases. Recently, our group has performed a new SNP-based linkage study in 19 non-BRCA1/2 families." "We found that a single family was linked to regions in two ...
2009 NOV 16 ... H2A ubiquitination for both DSBs and UV lesions, including the recruitment of 53BP1 and Brca1," wrote J.A. Marteijn and colleagues, Erasmus University. The researchers ...
2009 NOV 16 ... institution retrospective chart review of patients with ovarian cancer Who Underwent BRCA1/BRCA2 genetic testing." "Thirty-three percent of our sample (n = 100) ...
2009 NOV 23 ... for recruitment if they had a family history of prostate cancer, were black or had a BRCA1/2 mutation. Recruitment methods were analyzed using standard statistical methods with ...
2009 NOV 23 ... genome stability and may interact with some important cancer-related proteins such as BRCA1. Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive ...
2009 NOV 16 ... According to a study from the United States, "About half of unaffected BRCA1/2 carriers have a negative family history, confounding efforts toward presymptomatic ...
2009 NOV 3 ... increased DNA damage due to the absence of the full-length form of the tumor suppressor Brca1 (Brca1(Delta 11/Delta 11)), we show that deletion of ...
2009 NOV 16 ... "Discovery of mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 can have emotional consequences for both the tested individual and his or her ...
2009 NOV 16 ... mother was diagnosed with breast cancer and tested positive for the recently identified BRCA1 gene, indicating a genetic predisposition to breast cancer. "I spent about ...
2009 NOV 9 ... breast or ovarian cancer. Lymphocyte specimens from peripheral blood were processed for BRCA1 and BRCA2 by direct sequencing. Sixteen percent (54/337) of patients had a strong family ...
2009 NOV 23 ... in the journal Genetic Testing and Molecular Biomarkers, "Germline mutations in the BRCA1/2 genes contribute to most of inherited breast and ovarian cancers. We analyzed a family ...
2009 NOV 16 ... Data detailed in 'Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers' have been presented. According to a study from Cambridge, ...
2009 NOV 16 ... we suggest that As[III] could be exploited as a therapy for HR-deficient tumours such as BRCA1 and BRCA2 mutated breast and ovarian cancers." Ying and colleagues ...
2009 NOV 16 ... "Our case report presents the fourth case in which a de novo germline mutation in a BRCA1/2 gene has been identified." Marshall and colleagues published their study ...
2009 NOV 9 ... staining for FOXP1 was performed in 126 familial breast carcinomas comprising 35 BRCA1, 34 BRCA2 and 57 BRCAX. Nuclear FOXP1 expression ranged from focal weak to widespread ...
2009 NOV 16 ... between 2004 and 2008. We screened all 564 patients for nine founder mutations: four in BRCA1, three in BRCA2 and one each in PALB2 and CHEK2. We also studied 6433 DNA samples from ...
2009 NOV 2 ... strategies exist that can decrease the morbidity and mortality associated with having a BRCA1 or BRCA2 mutation. Unfortunately, the task of identifying these patients at high risk is ...
2009 NOV 9 ... respect to molecular changes and immunophenotype. Invasive breast cancers in germline BRCA1 and BRCA2 mutation carriers have a distinct ''basal'' and ''luminal'' ...
2009 NOV 16 ... for breast cancer risk recommended face-to-face disclosure of genetic testing results, BRCA1/2 testing results are increasingly provided by telephone. The few existing studies on ...
