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2009 JUL 13 ... signal for apical transcytosis.' "Polarized epithelial cells contain apical and basolateral surfaces with distinct protein compositions. To establish and maintain this asymmetry, ... investigators in the United States report. "Signals for basolateral sorting are generally located in the cytoplasmic domain of the protein, whereas signals for ...
2009 AUG 11 ... of polarized epithelial cells. Mutation of the tyrosine- and dileucine-containing basolateral sorting signal, YLLV, in the cytoplasmic domain of BMRF-2 led to the failure of its accumulation in the ...
2009 JAN 5 ... contains a dileucine motif that constitutes the smallest essential component of its basolateral sorting signal. NKCC1 lacking this motif behaves as an apical protein. Examination of the NKCC gene ...
2005 AUG 22 ... identification and structural determination of the M-3 muscarinic acetylcholine receptor basolateral sorting signal.
"Muscarinic acetylcholine receptors comprise a family of ...
2007 NOV 6 ... in the cytoplasmic tail of the type II transforming growth factor-beta receptor controls basolateral delivery,' have been published. According to recent research published in the journal ... domain acts as a cell membrane retention signal, and it supports the hypothesis that T2R sorting occurs from an intracellular compartment."
Murphy and colleagues ...
2007 JAN 22 ... in primary neurons. We further demonstrate a direct interaction of PAT1a with the basolateral sorting signal of APP/APLPs. Moreover, we provide evidence for a direct role of PAT1a in APP/APLP ...
2007 AUG 7 ... a delayed exit from the detergent-resistant microdomain, failure of oligomerization, and basolateral missorting of Gp135. Furthermore, the basolaterally missorted EBP50-binding defective ... presumably depending on the apical targeting of Gp135. We show that correct apical sorting of Gp1.35 depends on a bipartite signal composed of an extracellular ...
2007 JUL 17 ... of its receptor into cholesterol-sensitive detergent-resistant membranes confined to the basolateral surface/basolateral endosomes. A fraction of human transferrin receptor was also found ... "Cholesterol-rich membrane domains (e.g., lipid rafts) are thought to act as molecular sorting machines, capable of coordinating the organization of signal transduction pathways ...
