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2009 NOV 27 ... "Bile acid-binding proteins (BABPs) are cytosolic lipid chaperones that play central roles in driving bile ... of bile acid homeostasis and functional distribution within the cell. Understanding the mode of binding of bile acids with their cytoplasmic transporters is a key issue in providing ...
2009 NOV 23 ... plasmons on continuous or nanostructured noble-metal surfaces to detect molecular-binding events(1-4). Despite undisputed advantages, including spectral tunability(3), strong ... technology using a plasmonic metamaterial that is capable of supporting a guided mode in a porous nanorod layer. Benefiting from a substantial overlap between the probing ...
2009 NOV 16 ... "The major core promoter-binding factor in polymerase II transcription machinery is TFIID, a complex consisting of TBP, ... TFIID binding to established core promoter elements is not known. Here we analyzed the mode of TAF4b.TAF12 DNA binding and show that this complex binds DNA with high affinity. The ...
2009 NOV 10 ... pathway, ScoC negatively regulates FlgM via directly repressing flgM transcription by binding to two sites in the promoter region of the flgM operon. Our studies also show that the ... and colleagues. The researchers concluded: "Thus, ScoC shows a dual mode of downregulation of FlgM, via both SinR-dependent and -independent pathways, which ...
2009 NOV 16 ... inhibitors. We demonstrate that conformational flexibility results in an unexpected binding mode identifying a new hydrophobic pocket on the enzyme. Importantly this plasticity allows ...
2009 NOV 16 ... Tongji University. The researchers concluded: "Analysis of the two binding interfaces sheds light on atomic details of the inhibitor specificity and also promises ... 2, consisting of residues P5 Cys(141) to P5' Glu(150), binds trypsin in the classic mode by employing a two-disulfide-bonded loop," wrote R. Bao and colleagues, Tongji ...
2009 NOV 17 ... simple methods. Here, we present an approach for characterizing both protein-ligand binding as well as protein hydrodynamic radius in one operation combining electrophoresis and ... glycoprotein and albumin interacting with the drug propranolol in a frontal analysis mode. Upon introduction of the propranolol-protein sample, voltage is initially applied to ...
2009 NOV 9 ... 'Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors,' are detailed in a ...
2009 NOV 9 ... proline-rich (SerPro)(5) substrate. This ternary complex captures the competent mode of binding of the peptide substrate, being bound in a left handed (poly) L-proline type II ...
2009 NOV 9 ... docking in conjunction with molecular dynamics (MD) simulation was used to explore the binding mode of MG132. Two conformations with the lowest docking energy were selected as the ...
2009 NOV 23 ... the three-dimensional structures of protein-DNA complexes, here we show that the binding of arginine residues to narrow minor grooves is a widely used mode for protein-DNA ...
2009 NOV 9 ... for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site," wrote T. Mogi and colleagues, University of Tokyo. ... Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode was mixed-type for quinone-dependent activity and noncompetitive for succinate-dependent ...
2009 NOV 9 ... and colleagues, Simon Fraser University. The researchers concluded: "The binding mode of arylomycin A(2) in this 2.0 angstrom resolution ternary complex is compared to that ...
2009 NOV 9 ... leprae RecA Intein, a LAGLIDADG Homing Endonuclease, Reveals a Unique Mode of DNA Binding, Helical Distortion, and Cleavage Compared with a Canonical LAGLIDADG Homing ...
2009 NOV 16 ... The mutant strain had an altered membrane phospholipid pattern and showed decreased binding of dermcidin to the bacterial surface, indicating that dermcidin interacts with membrane ... bacterial surface, indicating that dermcidin interacts with membrane phospholipids. The mode of this interaction was direct, as shown by assays of dermcidin binding to phospholipid ...
2009 NOV 9 ... the orthogonal coordination of azoles. Upon substitution of Gly(243) by an alanine, the binding mode of azoles and some arylamines reverted from type II to type I because of hydrophobic and ...
2009 NOV 16 ... the present study is clear, consistent and could give a rational explanation for the binding mode of the best selected ligand." Chen and colleagues published their study in ...
2009 NOV 25 ... reveal that OPA is preferably attached to the aluminum oxide islands via the bidentate binding mode whereas the tridentate mode is dominating in case of OPA attached to the gold areas." ...
