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2009 NOV 23 ... is not known." "The aim of the present study was to determine whether brain glucose hypersensitivity present in obese Zucker rats is related to an alteration in ... terms of glucose sensing is linked to an abnormal redox signaling, which originates from mitochondria dysfunction. Diabetes 58:2189-2197, 2009." Colombani and colleagues ...
2009 NOV 1 ... epilepsy, encephalopathy and Alpers' syndrome (a fatal childhood disease leading to brain and liver failure). Keywords: HIV/AIDS, Biochemistry, Chemicals, Chemistry, ... known as Pol (gamma) (pol gamma), that is responsible for DNA replication in human mitochondria. When mitochondria are working normally, they produce most of the energy ...
2009 OCT 5 ... the effect of IPC on ischemia/reperfusion-induced mitochondrial apoptosis. Global brain ischemia was induced by permanent occlusion of vertebral arteries and temporal occlusion ... was induced. With respect to mitochondrial apoptosis initiation, translocation of p53 to mitochondria was observed in hippocampus but not in cerebral cortex. However, level of both apoptotic ...
2009 OCT 5 ... Group, Dept. of Biomedical, Psychiatry University Clinic, Neurobiology Laboratory Brain Aging & Mental Health, Wilhelm Klein Str 27, CH-4025 Basel, Switzerland. ... in the pathogenesis of Alzheimer's disease (AD) and it has been recently proposed that mitochondria are involved in the biochemical pathway by which A beta can lead to neuronal ...
2009 NOV 2 ... (BCRP). These proteins are expressed in excretory organs, in the placenta and blood-brain barrier, and are involved in the transport of drugs and endogenous compounds." ... compounds." "Because some of these proteins are expressed in the mitochondria, this study was designed to determine whether BCRP is expressed at a mitochondrial level ...
2009 OCT 6 ... 233 Spring St., New York, NY 10013, USA. Keywords: Slovakia, Kosice, Brain Ischemia, Ischemia, Molecular Neurobiology. This article was prepared by ... activity of mitochondrial enzyme MnSOD in cytoplasm, indicating release of MnSOD from mitochondria in the process of delayed neuronal death. Increased cytosolic cytochrome c and ...
2009 NOV 17 ... extensive networks, and peroxisomes were elongated in Drp1-null embryonic fibroblasts. Brain-specific Drp1 ablation caused developmental defects of the cerebellum in which Purkinje ... States, "The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria and peroxisomes. To understand the in vivo function of Drp1, complete and ...
2009 NOV 9 ... new potential targets for therapeutic intervention in neuroinflammatory disorders and brain cancer in particular." Martin and colleagues published their study in the ... was abrogated in the presence of allopurinol and DPI, but not by rotenone, discarding mitochondria as a ROS source. In addition, sPLA(2)-IIA triggered Ras and Raf-1 activation, with ...
2009 OCT 5 ... and complex I deficiency. These are often severe and progressive conditions that attack brain, muscles and numerous other parts of the body. Mitochondrial diseases are ... Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy ...
2009 NOV 29 ... The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that ... their search for answers about the neurodegeneration in GM1-gangliosidosis to the mitochondria, another intracellular compartment. Some of the mitochondria are connected to the ER via ...
2009 NOV 2 ... from the United States, "12/15-Lipoxygenase (12/15-LOX) is an important mediator of brain injury following experimental stroke in rodents. It contributes to neuronal death, but ... Data detailed in '12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress' have been presented. According to a study from the United ...
2009 OCT 6 ... 12.5. Neural cell-specific (NS) Drp1(-/-) mice die shortly after birth as a result of brain hypoplasia with apoptosis. Primary culture of NS-Drp1(-/-) mouse forebrain showed a ... number of neurites and defective synapse formation, thought to be due to aggregated mitochondria that failed to distribute properly within the cell processes. These defects were ...
2009 OCT 19 ... (alpha-syn) as amyloid fibrils in the intracellular Lewy bodies in various region of the brain. Current thinking suggests that an interaction between alpha-syn and dopamine (DA) leads ... oxidation could play a key role is the pathogenesis of PD by causing oxidative stress, mitochondria dysfunction and impairment of protein metabolism," wrote S.L. Leong and colleagues, ...
2009 OCT 5 ... outcome. Adjunct neuroprotective interventions must also be developed to ensure maximal brain tissue salvage. Targeting prodeath signaling pathways upstream of mitochondrial damage ... recanalization therapies and alternative therapeutic strategies are discussed concerning mitochondria-mediated cell death. Mitochondrial death-regulation pathways are divided into 3 ...
2009 NOV 2 ... at the onset of ischemia." Gurer and colleagues published their study in Brain Pathology (Astrocytes are More Resistant to Focal Cerebral Ischemia Than Neurons and Die ... integrity longer than neurons. EM confirmed that astrocyte ultrastructure including mitochondria and lysosomes disintegrated much later than that of neurons," wrote G. Gurer and ...
