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2009 APR 6 ... to target persistent reservoirs.
Our scientists have discovered that bryostatin-1, a potent PKC modulator, re-activates HIV-1 latency at concentrations that do not ...
2009 MAR 30 ... stress.
Scientists at Louisiana State University have discovered that bryostatin-1, a potent PKC modulator at nanomolar concentrations, activates protein kinase C-d ...
2009 JUL 6 -- According to a study from Clichy, France, "Acquired resistance to protein kinase C (PKC) modulators may explain the failure of clinical trials in patients with cancer. Herein, we established a human colon cancer cell line resistant to PEP005,......
2009 JUL 27 -- "Protein kinase C (PKC) is widely recognized as a therapeutic target in intractable diseases such as cancer, Alzheimer's disease (AD), and acquired immune deficiency syndrome (AIDS). While inhibition of PKC is a general therapeutic strategy for......
2009 MAY 4 -- The Food and Drug Administration (FDA) has given the Blanchette Rockefeller Neurosciences Institute (BRNI) the go-ahead to conduct Phase II clinical trials of Bryostatin for the treatment of Alzheimer's disease patients. The drug showed......
2009 JAN 13 -- "Palmerolide A (1) is a macrolide isolated from the Antarctic tunicate Synoicum adareanum that is of interest due to its potential as an antimelanoma drug. Biosynthesis is predicted to occur via a hybrid PKS-NRPS pathway within S. adareanum,......
2009 APR 27 -- According to a study from the United States, "Sud N, Kumar S, Wedgwood S, Black SM. Modulation of PKC delta signaling alters the shear stress-mediated increases in endothelial nitric oxide synthase transcription: role of STAT3."
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2009 NOV 1 ... stroke in humans, are a global unmet medical need." "Here, we report that bryostatin-1, a highly potent protein kinase C (PKC) activator, interrupts pathophysiological ...
2009 FEB 9 -- According to a study from the United States, "The putative modular polyketide synthase (PKS) that prescribes biosynthesis of the bryostatin natural products from the uncultured bacterial symbiont of the marine bryozoan Bugula neritina......
2009 OCT 19 -- Scientists discuss in 'Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells' new findings in life sciences. "Cytotoxic chemotherapies do not usually mediate the expression of an immunogenic gene......
2009 SEP 14 ... According to recent research from the United States, "Preclinical data suggested that bryostatin-1 (bryo) could potentiate the cytotoxicity of cisplatin when given prior to this drug. We ...
2009 JAN 6 -- "Of the concepts used to improve the efficiency of organic syntheses, two have been especially effective: atom economy(1) ( the use of routes in which most of the atoms present in the reactants also end up in the product) and......
2009 JAN 26 -- Researchers detail in 'Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI,' new data in non-hodgkin lymphoma. "An effective method for in vivo detection of early......
2008 SEP 15 -- Scientists at the Blanchette Rockefeller Neurosciences Institute (BRNI) have discovered that Bryostatin -- and a related class of drugs discovered at BRNI -- administered 24 hours after stroke can rescue and repair brain tissue. These findings......
2008 OCT 6 -- Research findings, 'Bryostatin 1 modulates beta-catenin subcellular localization and transcription activity through protein kinase D1 activation,' are discussed in a new report. "In recent years, the use of natural products for cancer......
2008 SEP 29 ... sought to determine the response rate and toxicity profile of sequential paclitaxel and bryostatin-1, a novel, selective inhibitor of protein kinase C, in patients with advanced esophageal ...
2008 DEC 29 ... SDF-1 in Jurkat cells. Bryostatin-5 is a member of the macrolactones, and its analogue bryostatin-1 is currently being evaluated in clinical trials for its chemotherapeutic potential. The ...
2008 NOV 24 ... of America report.
"Consequently, we examined the effects of chronic bryostatin-1, a PKC activator, on the cerebral ischemia/hypoxia-incluced impairment of synapses and ...
2008 AUG 25 ... implicated in learning and memory. This study investigated whether: 0) PKC activated by bryostatin-1 (Bryo) just before or just after sessions of classical conditioning was capable of ...
