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2009 NOV 29 ... its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares ... Laufs and Dr. Frank Giordano are trying to find out whether AIDS viruses can be used as gene delivery vehicles in genetherapy. Therefore, it is crucial for them to know where ...
Subject: Helmholtz Association of German Research Centres
2009 NOV 29 ... important for developing new strategies for combating AD and other diseases, including cancer and diabetes, in which the PKA and GSK-3 signaling pathways are centrally involved," ... A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's ... Disease, Enzymes, Kinase, Mental Health, Neurodegenerative, Pathology, Synthase, Therapy, Treatment, Research.This article was prepared by NewsRx Health & Science ...
2009 NOV 23 ... and 5-fluorouracile (CMF)-based chemotherapy for adjuvant treatment of breast cancer reduces the risk of relapse. In this exploratory study, we tested the feasibility of ... were analyzed. Two supervised class prediction approaches were used to identify gene markers that can best discriminate between patients who would experience relapse and ... City:Munich, Country:Germany, Breast Cancer, Breast Carcinoma, Chemotherapy, Drug Therapy, Drugs, Methotrexate Sodium, Oncology, Pharmaceuticals, Recurrence, Treatment, Women's ...
2009 NOV 27 ... that could someday be used to treat a variety of diseases, especially multiple types of cancer."There is a pressing need for drugs that target transcription factors, both ... as an oncologist, Bradner became deeply interested in a human protein called NOTCH. The gene encoding this protein is often damaged, or mutated, in patients with a form of blood ... published in the November 12 issue of Nature, lays the foundation for a new kind of therapy aimed directly at a critical human protein - one of a few thousand so-called ...
2009 NOV 23 ... United States, Charlottesville, Biotechnology, Bladder Cancer, Bladder Carcinoma, Cancer Gene Therapy, Chemotherapy, Drug Development, Drug Therapy, Enzymes, Genetics, Genomics, Kinase, ...
2009 NOV 23 ... methylation-specific PCR in urine sediments for sensitive/specific detection of bladder cancer has been identified previously. In this study, we have evaluated 10 DNA methylation ... According to recent research from Shanghai, People's Republic of China, "A 11-gene set by methylation-specific PCR in urine sediments for sensitive/specific detection of ... Tong University, State Key Laboratory Oncogenes & Related Genes, Cancer Epigenet & Gene Therapy Program, Shanghai Cancer Institute, LN 2200-25 Xietu Rd., Shanghai 200032, People's ...
2009 NOV 23 ... Gastroenterology, HBV, HCV, Hepatitis B Virus, Hepatitis C Virus, Hepatocellular Cancer, Hepatocellular Carcinoma, Hepatology, Infectious Disease, Liver Disease, Oncology, ... Several HBV factors have been implicated in hepatocarcinogenesis, including the HBx gene, the pre-S2/S gene and the HBV spliced protein. Furthermore, HBV can be integrated into ... proteins, have been shown to have oncogenic properties. For HBV infection, antiviral therapy and vaccination have been shown to decrease the risk of HCC," wrote J. Fung and ...
2009 NOV 23 ... as pain modulators. There is substantial interindividual variation in pain severity in cancer patients." "Therefore, we evaluated 59 single nucleotide polymorphisms in ... >T (rs8904) was predictive of severe pain (OR, 0.64; 95% CI, 0.43-0.93). In a multi-gene analysis, we found a gene-dose effect, with each protective genotype reducing the risk ... 10 = ''pain as bad as you can imagine'') at presentation before initiating cancer therapy. Reported analgesic use was abstracted from charts and converted to morphine equivalent ...
2009 NOV 23 ... SNS-01, Senesco's multiple myeloma drug candidate, at the 2009 American Association for Cancer Research (AACR)-National Cancer Institute (NCI)-European Organization for Research and ... 19th, in Boston, MA. Ms. Taylor's abstract will be presented at a session entitled, "Gene Therapies", which will run from 12:30 PM until 2:30 PM on Monday, November 16th. ... Drug Development, Hematology, Multiple Myeloma, Myeloma, Oncology, Pharmaceuticals, Therapy, Treatment, Senesco Technologies Inc. This article was prepared by Biotech ...
2009 NOV 23 ... PSF-binding RNA expression in tumor cells is a potential therapeutic strategy for cancer." Wang and colleagues published their study in Proceedings of the National ... tumor promotion by VL30-1 RNA involves a trans effect rather than a cis effect on gene transcription. Expression of VL30-1 RNA is 5- to 8-fold higher in mouse tumor lines than ... Country:People's Republic of China, Cancer, Cell Proliferation, Melanoma, Oncology, Therapy, Treatment, Tumor Suppression, Sichuan University. This article was ...
2009 NOV 23 ... Fresh data on bladder cancer are presented in the report 'Differential effects of Nucleostemin suppression on cell ... apoptosis in the bladder cancer cell lines 5637 and SW1710.' "The Nucleostemin (NS) gene encodes a nucleolar protein enriched in adult and embryonic stem cells. NS is thought to ... Biology, Cell Proliferation, Diagnosis, Diagnostics, Embryonic Stem Cells, Enzymes, Gene Therapy, Genetics, Genomics, Oncology, Polymerase, Stem Cell Research. This article ...
2009 NOV 23 ... variant (rs12211228) is associated with NHL risk," scientists writing in the journal Cancer Causes & Control report. "We evaluated the independent roles of these IRF4 ... for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) ... Country:United States, Cancer, Hematology, Interferon, Non-Hodgkin Lymphoma, Oncology, Therapy, Treatment, National Institutes of Health. This article was prepared by ...
2009 NOV 23 ... According to a study from Hefei, People's Republic of China, "Cervical cancer is the most common malignant disease responsible for the deaths of a large number of ... the mechanisms that result in loss of control over STAT3 activity are not understood. Gene associated with Retinoid-Interferon-induced Mortality-19 (GRIM-19) is a ... Carcinoma, Oncology, Women's Health, Human Papillomavirus, HPV, Genetics, Interferon, Therapy, Treatment, Anhui Medical University. This article was prepared by Biotech ...
2009 NOV 23 ... with a strength that is better than any other prognostic factor in epithelial ovarian cancer including FIGO stage," wrote K.M. Jochumsen and colleagues, Odense University. ... "The purpose was to find a gene expression profile that could distinguish short-term from long-term survivors in our ... Country:Denmark, Gynecology, Obstetrics, Oncology, Ovarian Cancer, Ovarian Carcinoma, Therapy, Treatment, Women's Health, Odense University. This article was prepared ...
2009 NOV 23 ... investigate the association of IFN-gamma T/A gene polymorphism with the risk of cervical cancer. Case-control study. Uttar Pradesh State in India. Sample Two hundred cases with ... Interferon, Interferon Alfa-2b, Interferon Gamma, Intron, Oncology, Pharmaceuticals, Therapy, Treatment, Women's Health. This article was prepared by Biotech Business ...
2009 NOV 23 ... According to recent research from Lucknow, India, "Etiology of cervical cancer is associated with excessive inflammation mediated tumorigenesis. Pro and ... was designed to evaluate the association of TNFA (-308G >A) and IL-10 (-819C >T) gene polymorphism with risk of cervical cancer. One hundred fifty histopathologically ... Cervical Carcinoma, Cytokines, Cytology, Gynecology, Inflammation, Necrosis, Oncology, Therapy, Treatment, Women's Health. This article was prepared by Biotech Business ...
2009 NOV 23 ... carrying the gene for human preproenkephalin in patients with intractable pain from cancer. The second trial will test a vector carrying the gene for glutamic acid decarboxylase ... Michigan Department of Neurology have received a $1.8 million grant to develop a novel therapy for neuropathic pain, a difficult-to-treat condition in which patients experience pain ...
2009 NOV 23 ... beta 2 subunit gene may influence therapeutic responsiveness to cessation medications. (Cancer Epidemiol Biomarkers Prev 2009; 18(10):2608-12)." Perkins and colleagues ... for nicotinic acetylcholine receptors may influence response to nicotine replacement therapy for smoking cessation. We examined the association of a 3' untranslated region ...
