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2009 OCT 19 ... allowing the phosphorylation of Net1 by mitotic cyclin-dependent kinase (Cdk) (Clb2-Cdk1). However, the function of another FEAR component, the Polo-like kinase Cdc5, remains ... that Cdc5 promotes Cdc14 release primarily by stimulating the degradation of Swe1, the inhibitory kinase for mitotic Cdk. First, we found that deletion of SWE1 partially suppresses the ...
2009 NOV 2 ... of the centrosome. Phosphorylation of plectin by cyclin-dependent kinase 1/cyclin B (CDK1/CycB) kinase has been reported to abolish its cross-linking function during mitosis. ... it competed with endogenous plectin and inhibited the BRCA2-plectin interaction. This inhibitory effect resulted in dissociation of the centrosomes from the nucleus and increased the ...
2009 NOV 9 ... death, and in mitotic catastrophe. We show here that the mitosis-promoting kinase, cdk1-cyclin B1, suppresses apoptosis upstream of mitochondrial cytochrome c release by ... stimuli transduced by caspase-2, cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, ...
2009 APR 20 ... that the death effector domain-containing DEDD impedes mitotic progression by inhibiting Cdk1 (cyclin-dependent kinase 1) and thus maintains an increase of cell size during the ... downstream of phosphatidylinositol 3-kinase, and supports its activity by preventing inhibitory phosphorylation of S6K1 brought about by Cdk1 during the mitotic phase. DEDD-/- cells ...
2009 JUL 13 ... cell cycle transitions controlled by the ubiquitous cyclin-dependent kinaseCdk1 (refs 1-4). The proteins that control Cdk1 activity are well described but their links ... middle of interphase cells, and these nodes contain the Cdk1 inhibitor Wee1, the Wee1-inhibitory kinases Cdr1 (also known as Nim1) and Cdr2, and the anillin-like protein Mid1. Cdr2 ...
2009 JUN 1 ... "Forced expression of Cdc25B inappropriately upregulated the activity of Cdk1 and Cdk2, by reducing levels of inhibitory phosphorylation. In cells lacking p14ARF, p53 ... activity. Here it is shown that this is accompanied by inappropriate cyclin-dependent kinase activation and premature mitotic entry, leading to both p53-dependent and independent ...
2009 FEB 9 ... Jin and colleagues published their study in Genetics (Drosophila Myt1 Is the Major Cdk1 Inhibitory Kinase for Wing Imaginal Disc Development. Genetics, 2008;180(4):2123-2133).
For ...
2009 APR 20 ... Maturation-Promoting Factor (MPF), comprised of a catalytic Cyclin-dependent kinase-1 (Cdk1) and a regulatory subunit cyclin B and results in germinal vesicle breakdown (GVBD). ... and MPF inhibition remains unclear. Cdc25 phosphatases can activate Cdks by removing inhibitory phosphates from Cdks. Thus one method for sustaining prophase arrest could be inhibition ...
2009 MAY 4 ... TCCSUP, 5637, HT1376, and HT1197). Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to ... A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. The increase of p21/WAF1 protein ...
2009 MAY 19 ... and establishes G1. Proteolysis of cyclin B is the major known mechanism that turns off Cdk1 during mitotic exit."
"Here, we show that mitotic exit also ... "Here, we show that mitotic exit also activates pathways that catalyze inhibitory phosphorylation of Cdk1, a mechanism previously known to repress Cdk1 only during S and ... in the journal Molecular Biology of the Cell, "Inactivation of cyclin-dependent kinase (Cdk) 1 promotes exit from mitosis and establishes G1. Proteolysis of cyclin B is the ...
2009 AUG 3 ... series of N-1H-indazole-1-carboxamides has been synthesized and their effects on both CDK1 / cyclin B and the K-562 (human chronic myelogenus leukemia) cell line were evaluated," ... Although they were able to moderately inhibit the leukemic cell line K-562 and to Show inhibitory activity against the Cdc2-Cyclin B kinase in the low micromolar range, they turned out ...
2009 JAN 12 ... however, inhibit the activity of certain cyclin-dependent kinases (CDKs), including CDK1, CDK2 and CDK5 both in vitro and in low potassium-treated neurons. Consistent with its ... affects any other protein kinase. These analyses demonstrated that PKRi has no major inhibitory effect on pro-apoptotic kinases such as the c-Jun N-terminal kinases, the p38 MAP ...
2008 AUG 18 ... publish new data in the report 'Nuclear HuR accumulation through phosphorylation by Cdk1.' "A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in ... in synchronous G2-phase cultures; its cytoplasmic levels increased by Cdk1-inhibitory interventions and declined in response to Cdk1-activating interventions. In keeping with ... target mRNAs. Here, we present evidence that HuR phosphorylation at S202 by the G2-phase kinase Cdk1 influences its subcellular distribution," researchers in the United States ...
2008 AUG 5 ... particular CDK is subject to Weel. regulation. Saccharomyces Weel (Swe1) inhibits Cdc28 (Cdk1) associated with the mitotic cyclin, Clb2, but not with the G, (Cln1, -2, and -3) or the ... "Weel kinases regulate the cell cycle through inhibitory phosphorylation of cyclin-dependent kinases (CDKs). Eukaryotic cells express multiple ... cyclin-dependent kinases (CDKs). Eukaryotic cells express multiple CDKs, each having a kinase subunit (Cdk) and a regulatory ''cyclin'' subunit that function at different stages ...
2008 DEC 22 ... on the mitotic spindles at metaphase. TSPY enhances while TSPX represses the cyclin B1-CDK1 phosphorylation activity. The inhibitory effect of TSPX on the cyclin B1-CDK1 complex ... homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. Oncogene, 2008;27(47):6141-6150).
For additional ...
2008 NOV 24 ... as evidenced by the inhibition of mitotic entry and decreased activity of the CyclinB/ Cdk1kinase. The inhibition of G2 progression induced through CAMP signaling is dependent on ... "CAMP signaling is known to have significant effects oil cell growth, either inhibitory or stimulatory depending oil the cell type. Study of cAMP-induced growth inhibition in ...
2008 NOV 10 ... from the G(2) phase into mitosis is regulated by the cyclin-dependent protein kinase 1 (CDK1) in complex with cyclin B. CDK1 activity is controlled by both inhibitory ...
2008 OCT 20 ... and oxidative detoxification. Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphorylates FOXO1 at serine 249 (S249) in vitro and in vivo," ... also inhibits FOXO1-induced apoptosis in PCa cells. Moreover, we demonstrate that the inhibitory effect of FOXO1 on Ras oncogene-induced colony formation in fibroblasts is diminished by ...
2008 NOV 17 ... inhibition of both CDKs and CK1. In particular, derivative 13a was a potent inhibitor of CDK1/cyclin B (IC50: 220 nM), CDK5/p25 (IC50: 80 nM), and CK1 (IC50: 14 nM). Modeling of ... differ by the substituent on the C-6 position. These compounds were screened for kinaseinhibitory activities and antiproliferative effects. Several biaryl derivatives displayed potent ...
