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2009 NOV 23 ... Quercetin, an ubiquitous bioactive flavonol, inhibits cells proliferation, induces cell cycle arrest and apoptosis in different cancer cell types," scientists in Changhua, Taiwan report. ...
2009 NOV 23 ... is well established that cAMP signaling is an important regulator of the oocyte meiotic cellcycle. Conversely, the function of cGMP during oocyte maturation is less clear," ... suggesting that an intraoocyte pool of cGMP is involved in the maintenance of meiotic arrest. This effect is absent in PDE3A-deficient oocytes," wrote S. Vaccari and colleagues, ...
2009 NOV 24 ... of Rome. The researchers concluded: "In normal human primary fibroblasts cell cycle arrest at the G(1)/S transition can be triggered shortly after irradiation and maintained for ...
2009 NOV 23 ... to precisely dissect the signaling pathway(s) responsible for the naphthalimide-induced cell cycle arrest in human colon carcinoma HCT116 cells," scientists in Shanghai, People's Republic of ...
2009 NOV 23 ... findings, 'Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth,' are discussed in a new report. "The aim of this study was to determine ... "Staining with propidium iodide followed by flow cytometry was used to detect cell cycle stages. Heat denaturation and molecular fractionation experiments were also performed. ... to determine whether normal human embryonic stem cells (hESC) would secrete factors that arrest growth of human epithelial cancer cell lines. Cell proliferation was examined using the ...
2009 NOV 23 ... "DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic stability(1,2). A key ... in mitosis gene A)-related kinase 11 (NEK11) is required for DNA damage-induced G2/M arrest. Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in ...
2009 NOV 24 ... Np63 downregulation and K1/K10 induction. Finally, loss of C/EBP alpha/beta induced stem cell gene expression signatures in the epidermis," wrote R.G. Lopez and colleagues. ... The researchers concluded: "C/EBPs, therefore, couple basal keratinocyte cell cycle exit to commitment to differentiation through E2F repression and DNA binding, ... transcriptional regulators that couple interfollicular basal keratinocyte proliferation arrest to commitment and differentiation are yet to be identified. Here we report that the ...
2009 NOV 24 ... and/or tissue-derived STC1 in regulating macrophage function. STC1 induces arrest of the cellcycle at the G1 phase and reduces cell necrosis and apoptosis in serum-starved ...
2009 NOV 17 ... died indicates that few cells had been able to survive hypoxic conditions and escape the cell-cyclearrest," wrote V. Raclavsky and colleagues, Palacky University. The ...
2009 NOV 23 ... of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) on cell viability, cell cycle arrest and apoptosis in CT-26 murine colorectal adenocarcinoma cells. For determining cell ...
2009 NOV 23 ... agreement with its roles in AML and in immature MDS cells, EVI1 was found to stimulate cell proliferation and inhibit differentiation in several experimental systems. In contrast, ... either of these proteins caused cells to accumulate in the G(O)/G(1)-phase of the cell cycle and moderately increased the rate of spontaneous apoptosis. However, when EVI1- or ... Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die ...
2009 NOV 23 ... diverse antitumor agents-cisplatin and methotrexate on the proliferation and cellcycle of two head and neck squamous cancer cell lines HEp-2 (wild type p53 gene, but HPV ... high S phase content observed in methotrexate-treated cells into a G1 and slight G2 arrest, while it sustained G2 arrest of the cells treated with cisplatin, along with the ...
2009 NOV 17 ... RNA processing. Tumor suppressor p53 coordinates crucial cellular processes, including cell-cyclearrest and DNA repair, in response to stress signals." ...
2009 NOV 23 ... complicated stress responses, including such responses as signaling pathway activation, cell cycle arrest, DNA repair, translesion DNA synthesis and mutagenesis. In the present study, 2-DE and ...
2009 NOV 23 ... Moreover, it was of interest to elucidate the role of nicotinic receptors as well as cellcycle and apoptosis in mechanism of action of these compounds. SH-SY5Y cells were ... (approximately 93%) protection against salsolinol-induced toxicity. Salsolinol caused an arrest of the cells in G(1)-phase of cell cycle and an increase in apoptotic indices that were ...
2009 NOV 23 ... cancer are presented in the report 'Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710.' "The Nucleostemin ...
2009 NOV 16 ... rapamycin (mTOR), a downstream target of phosphoinositide 3-kinase signaling, results in cell cycle arrest and apoptosis in multiple in vitro, and in vivo models of prostate cancer," scientists ...
2009 NOV 16 ... signaling induced by SDF1. Moreover, inhibition of Src activity induced G(1) cell cycle arrest; however, it had minimal effect on survival of Waldenstrom macroglobulinemia cells, and ...
2009 NOV 23 ... 72 that has been shown to have different biological properties regarding apoptosis and cell cycle arrest. Earlier studies have shown allele specific loss of heterozygosity (LOH) at this ...
2009 NOV 16 ... polymerase (PARP) inhibitors that were originally designed to protect cells from cell-death under stress conditions (e.g. stroke or inflammation), efficiently eradicate MCF-7 ... are apparently involved. The phenanthridine PJ-34 caused a permanent G2/M cell-cyclearrest and cell death within 48-72 hours in breast cancer MCF-7 and MDA231 cells. In ...
