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2009 SEP 14 ... of their research in Molecular Biology of the Cell (Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair. Molecular Biology of the Cell, 2009;20(14):3374-3389). For ...
2009 SEP 14 ... "GABA cell dysfunction in both schizophrenia (SZ) and bipolar disorder (BD) involves decreased ... One gene that is common to these 2 networks is cyclin D2, a key component of cell cycle regulation that shows increased expression in SZ, but decreased expression in BD," ... and DNA repair, the current study has examined the genes involved in the G(1) and G(2) checkpoints to generate new hypotheses regarding the regulation of the GABA cell phenotype in the ...
2009 SEP 14 ... of Kin4, regulating the kinase's phosphorylation and localization during an unperturbed cellcycle and during SPOC activation, thus defining the phosphatase as a key regulator of ... of the SPOC. Loss of PP2A-Rts1 function abrogates the SPOC but not other mitotic checkpoints," wrote L.Y. Chan and colleagues. The researchers concluded: "We further ...
2009 OCT 5 ... rise to two separate daughter cells. Defects in genome maintenance mechanisms such as cell cycle checkpoints and DNA repair can impact the segregation of the genome during mitosis leading to ...
2009 OCT 19 ... characteristic of many tumor cells is that they have lost this anchorage-dependent cell-cycle checkpoint, allowing them to proliferate without signals provided by their normal ... many cell types arrest cell-cycle progression in G1 phase as a result of Rb-dependent checkpoints. However, despite inactivation of p53 and Rb proteins, SV40LT-expressing cells retain ...
2009 OCT 5 ... "We previously hypothesized these low cancer levels were caused by enhanced cell cycle checkpoints that responded to inefficiently repaired DNA damage because Ku80-mutant fibroblasts ...
2009 AUG 24 ... According to a study from Tsukuba, Japan, "Wee1 is a tyrosine kinase regulating S-G2 cellcycle transition through the inactivating phosphorylation of CDC2. The inhibition of ... efficacy of DNA damaging agents, specifically in p53 negative tumors by abrogating S-G2 checkpoints, while normal cells with wild-type p53 are not severely damaged due to the intact ...
2009 NOV 2 ... in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines." "Glioblastomas showed a ... abnormalities of various cell-cycle checkpoint molecules displayed slippage of mitotic checkpoints and an increased proportion of hyperploid cells after ganp RNAi-treatment," wrote K. ...
2009 OCT 19 ... factor orchestrates the regulation of genes involved in the apoptotic response, cell cycle checkpoints, and cellular metabolism. FOXO1 is a putative tumor suppressor, and the expression of ...
2009 OCT 5 ... of this cytokine response required the DDR proteins ATM, NBS1 and CHK2, but not the cell-cycle arrest enforcers p53 and pRb. ATM was also essential for IL-6 secretion during ... The researchers concluded: "Thus, in addition to orchestrating cell-cycle checkpoints and DNA repair, a new and important role of the DDR is to allow damaged cells to ...
2009 OCT 12 ... target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies," scientists in ...
2009 OCT 5 ... "The retinoblastoma (Rb) tumor suppressor is a key regulator of cell cycle checkpoints but also protects against cell death induced by stresses such as DNA damage and death ...
2009 SEP 14 ... of effectors underlie proper checkpoint function," scientists writing in the journal CellCycle report. "The kinase Chk2, p21 and 14-3-3s have each been shown to be ... "DNA damage checkpoints are critical for preventing tumorigenesis and regulating the response of cells to ...
2009 OCT 19 ... cytokine-induced PI3K/AKT signaling is sufficient to override these DNA damage-induced cell cycle checkpoints, but may negatively impact hematopoietic cell viability. (Mol Cancer Res ...
2009 AUG 17 ... Solier and colleagues published the results of their research in CellCycle (The apoptotic ring A novel entity with phosphorylated histones H2AX and H2B and ... is conserved both in cancer and normal cells. The gamma-H2AX ring contains the activated checkpoints kinases, ATM, Chk2 and DNA-PK; the latter being the main effector for the apoptotic ...
2009 OCT 19 ... role in cancer biology by interfering with intracellular signalling pathways and cell cycle checkpoints. The 14-3-3 sigma isoform acts as a tumor suppressor and is often inactivated during ...
2009 OCT 27 ... "In yeast, assembly of the septins at the cell cortex is required for a series of key cellcycle events: bud-site selection, the ... series of key cell cycle events: bud-site selection, the morphogenesis and mitotic exit checkpoints, and cytokinesis. Here we establish that the Ccr4-Pop2-NOT mRNA deadenylase contributes ...
2009 OCT 5 ... journal Cancer Research, "Cdc25 dual specificity phosphatases positively regulate the cellcycle by activating cyclin-dependent kinase/cyclin complexes. Of the three mammalian ... degradation." "However, the roles of Cdc25B and Cdc25C in cell stress checkpoints remain inconclusive. We herein report that c-Jun NH2-terminal kinase (JNK) induces the ...
2009 SEP 14 ... The researchers concluded: "These results indicate that PTEN deficiency alters multiple cell cycle checkpoints possibly leaving less time for DNA damage repair and/or chromosome segregation as ...
