Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Google 2009 PageRank: #2 Among Top Health News and Media Publications
Google 2009 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2009 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2009 PageRank: #2 News and Media Site for the Pharmaceutical Industry
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
2009 NOV 24 ... using ELISA, immunoblot, and immunoprecipitation techniques, and for proliferation using cell counting after stimulation with CXCL12 or vehicle. The results of these studies identify ... to recent research from the United States, "The ectodomain shedding of epidermal growth factor receptor (EGFR) ligands, such as amphiregulin (AREG), by ADAMs (A Disintegrin And ... with exogenous CXCL12, and is not reduced subsequent to metalloprotease-or Src kinase-inhibition, in highly aggressive PC3 prostate cancer cells. These data also show that ...
2009 NOV 23 ... Data detailed in 'Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan' have been ... of GAPDH and reduces cell death. In addition, GAPDH interacts with transforming growth factor-beta-inducible early gene (TIEG2), a transcriptional activator for MAO B, and ... of glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-death cascade, rather than the inhibition of MAO B," scientists in the United States report. "Here, we provide ...
2009 NOV 23 ... Gratton, University of Montreal, Institute Rech Clinic Montreal, Laboratory Endothelial Cell Biology, 110 Pins Avenue W, Montreal, PQ H2W 1R7, Canada. The publisher of ... "Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine that also increases vascular permeability. ... and colleagues, University of Montreal. The researchers concluded: "Thus, inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC xi, is ...
2009 NOV 26 ... or C. perfringens spores in a liquid medium. The difference of C. perfringens vegetative cellgrowth between the treatment and control groups was 8.9 x 106 colony forming units ... and colleagues published their study in the Journal of Food Safety (GROWTH INHIBITION OF CLOSTRIDIUM PERFRINGENS VEGETATIVE CELLS AND SPORES USING CHICKEN IMMUNOGLOBULIN Y. ...
2009 NOV 23 ... Glomerulonephritis, which is the major cause of CKD, is characterized by mesangial cell proliferation and extracellular matrix deposition," scientists in Shizuoka, Japan ... significantly prevented the overexpression of type I collagen, fibronectin, transforming growth factor (TGF)-beta, and platelet-derived growth factor (PDGF) mRNA," wrote H. Sudo and ... Improves Glomerular Injury in Rats With Mesangioproliferative Glomerulonephritis via Inhibition of Proproliferative and Profibrotic Growth Factors. Journal of Pharmacological Sciences, ...
2009 NOV 23 ... relies on a variety of growth factors and signaling pathways to stimulate endothelial cell responses and establish functional blood vessels. Signaling through the vascular ... mediator of angiogenesis, a hallmark of tumor growth and metastasis." "Inhibition of signaling through VEGF has been clinically validated with FDA-approvals of ...
2009 NOV 23 ... the effects of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) on cell viability, cell cycle arrest and apoptosis in CT-26 murine colorectal adenocarcinoma ... adenocarcinoma cells in vitro via G2/M arrest and apoptosis, and CHM-1-P inhibited tumor growth in vivo." Chou and colleagues published their study in the Journal of ... mice inoculated with CT-26 cells orthotopic model. CHM-1 induced CT-26 cell viability inhibition and morphologic changes in a dose-dependent and time-dependent manner and the ...
2009 NOV 23 ... optimization of direct inhibition of the BCR-ABL kinase, inhibition of BCR-ABL-mediated cellgrowth via interruption of the BCR-ABL-mediated transcription, protein synthesis or ...
2009 NOV 23 ... in turn, stimulate effector cells such as T cells and NK cells. Lately, CD40-mediated cell growth inhibition and apoptosis have been in focus for the development of novel cancer treatment ...
2009 NOV 23 ... According to recent research from the United States, "A progressive reduction in beta-cell mass occurs in the evolution of diabetes. Thus understanding the mechanisms responsible ... beta-cell dysfunction via reduced Pdx1 expression. Inhibition of insulin/insulin-like growth factor (Igf) signalling followed by reduced Pdx1 expression is a common pathway induced ...
2009 NOV 23 ... aromatase inhibitor letrozole and/or curcumin. The tumor growth was monitored. Tumor cell apoptosis was detected in both control and treated groups. Fifty mice were successfully ... of Gynecological Cancer (Aromatase Inhibitor Letrozole in Synergy With Curcumin in the Inhibition of Xenografted Endometrial Carcinoma Growth. International Journal of Gynecological ...
2009 NOV 23 ... moiety and PE38KDEL, which is a truncated version of Pseudomonas exotoxin A, as a cell killing agent," scientists in the United States report. "It is highly ... "Expression of the human epidermal growth factor receptor 2 (HER2) is amplified in 25% to 30% of breast cancers and has been ... domain-mediated ADP-ribosylation of translation elongation factor 2 and, consequently, inhibition of protein synthesis as shown by protein expression analysis of HER2-positive cells ...
2009 NOV 23 ... in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cellgrowth in vitro," scientists in Tianjin, People's Republic of China report. ... cancer cells, the mRNA and protein levels of NF-kappa B1 are both suppressed, whereas inhibition of miR-9 results in an increase in the NF-kappa B1 expression level," wrote L.M. Guo ...
2009 NOV 23 ... Kulasekaran and colleagues published their study in American Journal of Respiratory Cell and Molecular Biology (Endothelin-1 and Transforming Growth Factor-beta 1 Independently ... 1. Activation of the PI3K/AKT pathway by ET-1 inhibits fibroblast apoptosis, and this inhibition is reversed by blockade of p38 MAPK or PI3K. TGF-beta 1 has been shown to attenuate ...
2009 NOV 24 ... supplementary 0.5 g/L of yeast extract maximized sulphate reduction on a per-cell basis, but at high concentrations of H2S it would be advisable to use 2 g/L to reduce ... efficiency. The aim of the study was to assess the sulphate reduction capacity and growth rates of the bacterium Desulfobacterium autotrophicum in batch culture media ... at high concentrations of H2S it would be advisable to use 2 g/L to reduce the product inhibition."Saeznavarrete and colleagues published their study in Desalination ...
2009 NOV 23 ... activity through an increase of aromatase protein phosphorylation in breast cancer cell lines." "In vivo labeling experiments and site-directed mutagenesis ... In addition, from our data it emerges that aromatase is a target of cross talk between growth factor receptors and estrogen receptor alpha signaling," wrote S. Catalano and ... of nonreceptor tyrosine-kinase c-Src in E-2-stimulated aromatase activity because inhibition of its signaling abrogated the up-regulatory effects induced by E-2 on aromatase ...
2009 NOV 23 ... an alternately spliced variant form of PAX6, is expressed in pancreatic carcinoma cell lines at higher levels than the canonical PAX6 protein. Both protein forms of PAX6 bind ... of the MET gene. In addition, inhibition of PAX6 transcripts leads to a decline in cell growth and survival, differentiation, and a concurrent reduction of MET protein expression," ...
2009 NOV 24 ... A report, 'The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and ... 3-nitropropionic acid-induced toxicity. We also demonstrated that activation of ERKs by growth factors ameliorated the bioenergetics compromise and reduced cellular toxicity induced ... and sufficient for the increased dependency on glucose utilization. Pharmacological inhibition of ERKs not only abrogated bioenergetics adaptation but also reduced the activation of ...
2009 NOV 27 ... and two phenol derivatives. The inhibition of the degradation compounds on the cellgrowth and lipid productivity of the selected oleaginous yeasts were examined. Acetic ...
2009 NOV 23 ... "Annexin A2 is involved in multiple cellular processes, including cell survival, growth, division, and differentiation. A lack of annexin A2 makes cells more ... for apoptotic stimuli-induced annexin A2 cleavage, which contributes to cell cycle inhibition and apoptosis. Annexin A2 was persistently expressed around the proliferative but not ...
