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2009 SEP 14 ... cases have common genetic alterations, but also that relapsed samples frequently lose chromosomal markers present at diagnosis, suggesting that relapsed T-ALL emerges from an ancestral ...
2009 SEP 14 ... poison, etoposide, on mice bone marrow cells. The scoring of micronuclei, chromosomal aberrations, and mitotic activity were undertaken as markers of cyto- and ... cells of mice. These effects were dose dependent. Etoposide induced marked biochemical alterations characteristic of oxidative stress including enhanced lipid peroxidation and reduction ...
2009 NOV 2 ... Current study results from the report, 'Chromosomal imbalances and partial uniparental disomies in primary central nervous system ... recent research published in the journal Leukemia, "To determine the pattern of genetic alterations in primary central nervous system lymphomas (PCNSL), 19 PCNSL were studied by ...
2009 OCT 5 ... from the United States, "Aggressive forms of cancer are often defined by recurrent chromosomal alterations, yet in most cases, the causal or contributing genetic components remain poorly ...
2009 NOV 2 ... increased risk of ALL. But patients with Down syndrome rarely have the genetic and chromosomal alterations commonly associated with childhood ALL. Until recently the genetic basis of the elevated ...
2009 SEP 21 ... fluorescence in situ hybridization (FISH) analysis, all tumours displayed characteristic chromosomal abnormalities. Point mutations of both FGFR3 and p53 genes were identified in one case. ... evaluate the histological and immunohistochemical characteristics and molecular genetic alterations in these neoplasms." "Four patients developing urothelial neoplasms after ...
2009 NOV 16 ... are required to attain infinite proliferation. We show here that the disruption of human chromosomal interval at 1q21.1 by SV40 integration can be an essential step for cellular ... essential, it is not sufficient for cellular immortalization, suggesting that additional alterations in cellular genes are required to attain infinite proliferation. We show here that the ...
2009 NOV 17 ... whose clinical features were not typical of known disorders." "Rare chromosomal copy number changes were detected in eight patients, four de novo imbalances and four ... patients, four de novo imbalances and four inherited from a normal parent. The de novo alterations define candidate chromosome segments likely to harbor dosage-sensitive genes related to ...
2009 OCT 5 ... rearrangement if not properly executed or regulated." "As these types of chromosomal alterations threaten the cell's and the organism's very own survival, multiple systems are ...
2009 NOV 9 ... multiplex tumours from eight hereditary cases, was analysed for copy number changes by chromosomal comparative genomic hybridisation (CGH) and/or for allelic changes at chromosomes 7 and ... were compared with the cytological characteristics of the tumours. The results showed alterations of chromosomes 7 and 17 at similar frequencies in papillary RCTs with characteristics ...
2009 NOV 3 ... and immunodeficient hosts and the vector within the first few days after inoculation. Chromosomal complementation of the mutant with native bb0323 and phenotypic analysis in vivo ... B. burgdorferi did not affect microbial survival in vitro, despite considerable alterations in growth kinetics and cell morphology. The bb0323 mutants were unable to infect either ...
2009 NOV 9 ... or a premature termination codon in LSAMP exon 2. This SNP genotyping study identified chromosomal aberrations associated with disease progression in OS and disclosed LSAMP as a novel ... researchers in the United States report. "Certain recurrent cytogenetic alterations were more frequent in recurrent/metastatic than in primary OS. These included deletion ...
2009 OCT 5 ... "Chromosomal rearrangements involving erythroblast transformation specific (ETS) family transcription ... (ETS) family transcription factors were recently defined as the most common genetic alterations in human prostate cancer. Despite their prevalence, it is unclear what quantitative role ...
2009 NOV 23 ... bone tumor, subungual exostosis. The findings of this study expand our knowledge of chromosomal alterations in chondromyxoid fibroma, identify COL12A1 as the likely gene candidate within the ...
2009 OCT 19 ... Navarro and colleagues published their study in Cancer Research (MicroRNA Expression, Chromosomal Alterations, and Immunoglobulin Variable Heavy Chain Hypermutations in Mantle Cell Lymphomas. Cancer ...
2009 SEP 14 ... to regional lymph nodes. The development of these familial cancers does not require chromosomal gains or losses, a high level of microsatellite instability, or the presence of ... short lifespan would prevent the accumulation of somatic genetic mutations or epigenetic alterations necessary for tumor progression," scientists writing in the journal Cancer Research ...
2009 NOV 17 ... expression (GE) data with other types of gene information, such as copy number (CN) and chromosomal localization, still represents a computational challenge in the genomic arena," ... proved to be effective in identifying discrete chromosomal regions of coordinated CN alterations and changes in transcriptional levels." Bicciato and colleagues published ...
2009 OCT 19 ... late-stage apoptotic events that lead to internucleosomal DNA fragmentation, maintaining chromosomal integrity probably in order to sustain metabolic capacity and hepatic elimination of ... induced by UV-C light in these cells is caspase-dependent and is accompanied by alterations in apoptosis-related gene expression such as up-regulation of proapoptotic bcl-2 family ...
2009 OCT 6 ... recombination events. Such a high-density composition of various mechanisms in a small chromosomal interval exemplifies the evolution of gene regulation and allelic diversity in general. ... many of the above mechanisms are of somatic origin. In contrast to animals, somatic alterations can easily be transmitted through meiosis because the germline in plants is contiguous ...
2009 OCT 12 ... presented. According to a study from Debrecen, Hungary, "Amplification of the 11q13 chromosomal region is a common event in primary melanomas. Several candidate genes are localized at ... Data detailed in 'Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma' have been ...
