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2009 NOV 23 ... survival, fertilization, early embryonic development, and meiotic spindle assembly and chromosome alignment in frozen-thawed human oocytes after slow-freezing and vitrification. A ... slow-freezing group (3 out of 25, 12.0%). There was a much higher percentage of oocyte abnormalities in terms of spindle assembly and chromosome alignment in the slow-freezing group (25 out ...
2009 NOV 24 ... arrest (78.99%) Most MI-arrested oocytes exhibited abnormalities in their spindles and chromosome configurations. Bcl2l10 RNA interference had an obvious effect on the activity of ...
2009 NOV 23 ... The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a ...
2009 NOV 23 ... oocytes from diabetic mice displayed a higher frequency of spindle defects and chromosome misalignment in meiosis, resulting in increased aneuploidy rates in ovulated oocytes," ... in nondisjunction leading to embryonic aneuploidy; second, structural and functional abnormalities of oocyte mitochondria, through maternal transmission, provide the embryo with a ...
2009 NOV 16 ... be identified," scientists in Ghent, Belgium report. "For several decades chromosome analysis has been the golden standard to detect these genomic imbalances. A major ... studies have indicated that in up to 50% of first trimester miscarriages, chromosomal abnormalities can be identified," scientists in Ghent, Belgium report. "For several ...
2009 NOV 2 ... expression displayed more malignant characteristics, with loss of heterozygosity on chromosome 10, epidermal growth factor receptor gene amplification, and significantly poorer ... percentage of S-phase cells and a cellular-senescence phenotype. MG cell lines harboring abnormalities of various cell-cycle checkpoint molecules displayed slippage of mitotic checkpoints and ...
2009 NOV 16 ... megakaryocytic maturation. The incidence of MDS is more in older age groups and frequent chromosome abnormalities reported to be monosomies 5 and 7. However, the data on cytogenetic changes in Indian ...
2009 NOV 2 ... specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chromosome 1p or 11q," scientists writing in the journal Current Oncology Reports report. ...
2009 NOV 2 ... "Genomic instability in colorectal cancer is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instability (MSI). MSI is the result of mutations ... a typical CIN phenotype, as characterized by an increase in the number of chromosomal abnormalities. Importantly, restoration of MMR proficiency completely inhibited induction of the CIN ...
2009 NOV 16 ... a study from Louvain, Belgium, "About 50% of spontaneous abortions are caused by fetal chromosome abnormalities. Identification of these abnormalities helps to estimate recurrence risks in future ...
2009 NOV 23 ... was not detected in any of the five cases examined by FISH; instead, extra copies of chromosome 18 were found in four of five cases. Finally, other cytogenetic abnormalities, including ...
2009 NOV 16 ... we analyzed 204 patients with diverse hematological malignancies accompanied by clonal chromosome 6p21 abnormalities, and found 8 additional patients with MDS with IER3 rearrangements ...
2009 NOV 23 ... Signature Genomics, which performs diagnostic genetic testing of chromosome abnormalities in individuals with unexplained mental retardation and/or birth defects, announced ...
2009 NOV 9 ... penetrant autosomal dominant condition resulting from a mutation in the C1QTNF5 gene on chromosome 11. Affected individuals develop bilateral loss of vision, dark-adaptation ... on chromosome 11. Affected individuals develop bilateral loss of vision, dark-adaptation abnormalities, fundus drusen-like yellow spots, midperipheral pigmentation, choroidal ...
2009 NOV 2 ... 1,851 cases with suspected/confirmed myelodysplastic or myeloproliferative diseases by chromosome banding and molecular analyses. Cytogenetics revealed aberrant karyotypes in 354 ... Investigators publish new data in the report 'Distribution of cytogenetic abnormalities in myelodysplastic syndromes, Philadelphia negative myeloproliferative neoplasms, and ...
2009 NOV 19 ... mutations. Further investigation revealed a loss of function mutation in SPRED1 on chromosome 15," wrote K.A. Lane and colleagues, Children's Hospital. The researchers ... this is the first description of a SPRED1 gene mutation resulting in ophthalmic abnormalities." Lane and colleagues published their study in Ophthalmic Plastic and ...
2009 NOV 3 ... capacities were determined. When ICSI-generated embryos were monitored for their chromosome integrity, some embryos with apparent normal morphology seen by conventional light ... is perturbing." "One major cause is thought to be embryonic chromosomal abnormalities. However, there is no direct evidence of how these occur or how they affect pregnancy ...
2009 NOV 16 ... Genetic analysis revealed three novel mutations in the calcium channel gene CACNA1A (chromosome 19p13). The two children had the same genetic abnormality as their parents," wrote P. ... well to acetazolamide. Two children were found to have both clinical and genetic abnormalities. At 23 months, one child started to have short attacks of imbalance mimicking benign ...
2009 NOV 9 ... 93 of 631 cases (14.7%), the most frequent abnormalities being +8, +4, -Y, del(9q), +21. Chromosome aberrations in NPM1-mutated AML were similar to, but occurred less frequently than ...