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2009 OCT 19 ... awaken errant pDCs to their proper duty. Researchers found that when compounds known as CpG ODNs (cytosine phosphate guanine oligodeoxynucleotides) attach to key receptors on the ...
2009 JUL 27 ... we sought to determine whether combined treatment with anti-CD40 mAb (alpha CD40) and CpG-containing oligodeoxynucleotides (CpG) could exert immunotherapeutic effects." ...
2009 AUG 31 ... Marburg, Germany report. "Recent work has proven the efficacy of synthetic CpG-Oligodeoxynucleotides (ODN) as inducers and adjuvants for a strong Th1-response and ...
2009 JUN 1 ... "Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several ...
2009 JUN 1 ... A report, 'CpG-ODN enhances ingestion of apoptotic neutrophils by macrophages,' is newly published ... the ability of macrophages to ingest apoptotic neutrophils after activated by synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODN) in vitro."
"The results showed ...
2009 OCT 5 ... priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages,' are detailed in a study published in Immunology. ... against infection. In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the ...
2009 AUG 10 ... States report. "Similarly, agonists for Toll-Like Receptors (TLR) such as CpG oligodeoxynucleotides (TLR9 agonist) have activity against AB1 tumors. Combinations of CpG with CD40 ligand ...
2009 NOV 23 ... Although pDCs are resistant to novel therapies, targeting Toll-like receptors with CpG oligodeoxynucleotides both restores pDC immune function and abrogates pDC-induced MM cell growth," wrote D. ...
2009 OCT 5 ... mice vaccinated with a killed vaccine comprised of autoclaved L. major antigen (ALM)+ CpG oligodeoxynucleotides that protected against needle inoculation of parasites, showed delayed expression of ...
2009 MAY 25 ... Current study results from the report, 'Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung ... have been published. "Unmethylated cytosine-phosphorothioate-guanine containing oligodeoxynucleotides (CpG-ODN) is known as a ligand of toll-like receptor 9 (TLR9), which selectively ...
2009 MAY 25 ... using Fisher 344 rats, we examined the prophylactic use of different regimens of type-C CpG oligodeoxynucleotides (CpG-C ODN) on NK activity and metastatic dissemination in the context of pharmacologic ...
2009 SEP 14 ... challenge for anticancer therapy. Immunostimulatory oligodeoxynucleotides (ODN) with CpG motifs are ligands of TLR9, which prime spontaneous antitumor immunity, but are less ...
2009 OCT 12 ... PBC sera of Japanese and USA patients to explore the ethnic difference. Third, we used CpG oligodeoxynucleotides and a B cell mitogen to challenge ex vivo peripheral leukocytes from indirect ...
2009 AUG 18 ... in the phenotype of circulating antigen-presenting cells (APCs) and in the response to CpG oligodeoxynucleotides (ODN-CpG) correlate with disease activity," scientists in Medellin, Colombia report. ...
2009 SEP 7 ... "We have previously reported that vaccination with CpG oligodeoxynucleotides delivered concomitantly with live Leishmania major (Lm/CpG) eliminates lesions ...
2009 MAY 25 ... recognize unmethylated CpG motifs in bacterial DNA and synthetic immune stimulatory CpG oligodeoxynucleotides. HUVECs respond to CpG DNA with rapid phosphorylation of I kappa B-alpha and NF-kappa ...
2009 JUN 15 ... in the United States. Immunotherapy employing Toll-like receptor (TLR) ligands, such as CpG oligodeoxynucleotides (CpG-ODN), may serve as a potentially promising approach in the control of ovarian ...
2009 NOV 16 ... According to a study from Seoul, South Korea, "CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a ... published their study in the Journal of Korean Medical Science (The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation ...
2009 AUG 10 ... IFN-gamma-deficient mice compared with that in wild-type mice; (ii) In vivo injection of CpG-oligodeoxynucleotides (CpG-ODN) caused a marked reduction in the incidence of SCC in ...
