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2009 NOV 24 ... (LET = 28.5 keV/mu m) or X/gamma-rays, and endpoints related to cell cycle kinetics and DNA damage analysed. Following both type of irradiations, unsynchronized cells suffered an ...
2009 NOV 29 ... barrier for the water, which supports the hypothesis that it protects the spore DNA from toxic compounds. To be able to "see" what happens inside spores, the Lund ... they would in ordinary cells. When the temperature goes down, they fold up again, and no damage has been done to the cell," explains Erik Sunde.In their experiments the ...
2009 NOV 24 ... impaired by Mre11 complex hypomorphism, as the formation of telomere dysfunction-induced DNA damage foci was reduced in both cre-infected Mre11(ATLD1/ATLD1) Trf2(F/Delta) and Nbs1(Delta ...
2009 NOV 27 ... assay performed on whole blood, it was observed that CCl4 was capable of inducing mainly DNA damage class 4 and 3 frequencies, which was significantly reduced in groups that received both ...
2009 NOV 29 ... AIDS drugs.Like all retroviruses, the AIDS virus (HIV) integrates its DNA into the genome of the infected cell. As integration sites, HIV usually prefers active ... on the position, this process can result in permanent activation of oncogenes or other damage. Therefore, the researchers took a very close look by starting an analysis of more than ...
Subject: Helmholtz Association of German Research Centres
2009 NOV 24 ... genomic site in Saccharomyces cerevisiae and thus mimics a stabilized topoisomerase I-DNA cleavage complex. We took advantage of a mutant Flp recombinase that can introduce a ... pathways activated by a single genomic insult, and it allows the study of events at the damage site, which so far has been impossible to address.' This article was ...
2009 NOV 24 ... characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD chromatin remodelling complex as a key modulator of these ...
2009 NOV 25 ... this is not critical, but DNA electrotransfer may be unsuccessful due to heating-related DNA damage or denaturation."Lackovic and colleagues published their study in IEEE ...
2009 NOV 24 ... also depends on supply on NADPH required in repairing damage induced by chromate and on DNA integrity maintenance." Decorosi and colleagues published their study in ...
2009 NOV 23 ... In haploid prokaryotic cells, stress responses include error-free and error-prone DNA damage repair pathways, such as homologous recombination and translesion synthesis, ...
2009 NOV 23 ... care of most of the DNA copying. But enzymes in this family stall if they come across DNA damage, and that stalling endangers the replication process and could lead to cell death. ...
2009 NOV 25 ... I MHz or 100 MHz IBSEFs with field strengths exceeding 3 kV/m induces significant DNA damage. According to the numerical calculation of the electric field over a simplified cell ...
2009 NOV 27 ... bacteria (E coli and enterococci, and QPCR-based detection of enterococci), F+ (DNA and RNA) and somatic coliphages, the human-specific marker in Bacteroidales (HF marker), ... researchers concluded: "Given the clarity of the water, direct genomic damage of bacteria and coliphage, as well as indirect endogenous damage of bacteria, were ...
2009 NOV 27 ... (CHO) cells was modified to include liquid holding recovery time to measure genomic DNA damage and repair kinetics of three monoHAAs: chloroacetic acid (CAA), bromoacetic acid (BAN, ...
2009 NOV 24 ... of IL-6 markedly diminishes hyperoxic lung injury, hyperoxia-induced cell death, and DNA fragmentation, and enhances Bcl-2 expression. We hypothesized that changes in the ... IL-6 overexpression in mice protects against hyperoxia-induced lung mitochondrial damage. The overexpression of Bcl-2 in vivo prolonged the survival of mice exposed to hyperoxia ...
2009 NOV 23 ... "DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. ... DPC site initiates HR and reactivates the stalled fork. DPCs activate both ATR and ATM damage response pathways, but there is a time lag between two responses," wrote T. Nakano and ...
2009 NOV 24 ... their effect on gamma-radiation induced lipid peroxidation, protein carbonylation and DNA damage. The results indicated that E1 with higher free radical scavenging ability is also a ...
2009 NOV 23 ... According to a study from Havana, Cuba, "CIGB-230, a mixture of a DNA plasmid expressing hepatitis C virus (HCV) structural antigens and a HCV recombinant ... There was an absence of detectable adverse effects on key toxicology parameters and no damage evidenced in inspected organs and tissues," wrote D. Bacardi and colleagues. ...
2009 NOV 23 ... not clearly understood yet. The aim of the study was to explore characteristics of DNA damage and TP53 gene mutations in lung cancer from Hungary." "Tissue samples ...
2009 NOV 23 ... of ROS overwhelms the body's normal defense mechanisms, oxidative damage to cellular DNA occurs and can lead to cell death. Research indicates a strong link between oxidative ...
