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2009 NOV 27 ... According to a study from the United States, "DNA repair enzymes are essential for maintaining the integrity of the DNA sequence. Unfortunately, ...
2009 NOV 24 ... (LET = 28.5 keV/mu m) or X/gamma-rays, and endpoints related to cell cycle kinetics and DNA damage analysed. Following both type of irradiations, unsynchronized cells suffered an ... proteins, such as TP53 and CDKN1A showed a clear LET-dependence. DSB induction and repair as measured by scoring for gamma-H2AX foci indicated that protons, with respect to ...
2009 NOV 23 ... 'RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair,' are detailed in a study published in Embo Reports. "Nuclear factor (NF)-kappaB is a ...
2009 NOV 23 ... medications may play a role or PM2.5 exposure may reduce the capacity to repairDNA damage in hypertensives," wrote J.Y. Kim and colleagues, Harvard University. ...
2009 NOV 23 ... aforementioned syndromes, including microsatellite instability, immunohistochemistry for DNA mismatch repair system proteins, and especially their mutations, is on the basis of ...
Subject: Hereditary Nonpolyposis Colorectal Cancer
2009 NOV 24 ... genomic site in Saccharomyces cerevisiae and thus mimics a stabilized topoisomerase I-DNA cleavage complex. We took advantage of a mutant Flp recombinase that can introduce a ... genome-wide. hence, a single protein-bound nick is enough to kill cells if functional repair pathways are lacking. the Flp-nick system can be used to dissect repair, checkpoint and ...
2009 NOV 23 ... with RAD51, which is an essential protein in the homologous recombinational repair of DNA double-strand breaks, and stimulates RAD51-mediated recombination reactions in vitro." ...
2009 NOV 24 ... "Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if not ... uses a short homologous sequence found in a third chromosome as a bridge to complete DSB repair, leading to chromosomal translocations. Such translocations are dramatically reduced ...
2009 NOV 23 ... is a consequence of activation in the Atm-Chk2 pathway. Udu seems not to be required for DNA repair, because both wild-type and udu embryos similarly respond to and recover from UV ...
2009 NOV 27 ... phosphorylation, and electron transport genes were downregulated. After 10 min, DNA repair was downregulated and the oprH gene that blocks the self-promoted uptake of ...
2009 NOV 23 ... responses, including such responses as signaling pathway activation, cell cycle arrest, DNA repair, translesion DNA synthesis and mutagenesis. In the present study, 2-DE and MALDI-TOF MS ...
2009 NOV 23 ... are ubiquitous enzymes that play an essential role in the control of replicative DNA synthesis and share structural and functional homology among different prokaryotic and ... Investigators publish new data in the report 'Type II topoisomerases--inhibitors, repair mechanisms and mutations.' According to a study from Hamburg, Germany, "Type II ...
2009 NOV 23 ... (PARP) inhibitors. The PARP inhibitors represent a novel therapeutic strategy in DNA-repair-deficient tumors, such as triple-negative breast cancer. "PARP ...
2009 NOV 23 ... regulate the expressions of cell proliferation- and apoptosis-related genes and DNA repair-related genes." Chang and colleagues published their study in Brazilian ...
2009 NOV 27 ... liquid holding period. Nuclei from CHO cells treated with BAA showed the lowest rate of DNA repair (t(50) = 296 min) compared to that of CAA or IAA (t(50) = 134 and 84 min, respectively). ...
2009 NOV 23 ... and brain. It is caused by germline mutations in genes encoding for components of the DNA mismatch repair system," scientists in the United States report. "We ...
2009 NOV 23 ... "DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. ... "In bacteria, DPCs with small CLPs are eliminated by nucleotide excision repair (NER), whereas oversized DPCs are processed exclusively by RecBCD-dependent homologous ...
2009 NOV 23 ... arginine residues. This multifunctional protein acts in transcriptional co-activation, DNA-recombination, -pairing and -repair, in splicing, and mRNA transport," scientists in ...
