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2009 OCT 12 ... fold was enhanced about 80-fold by directed evolution using error-prone PCR and DNA shuffling. Kinetic studies of the mutant enzyme (Hyb-S4M94) demonstrated that the enzyme had ...
2009 JUL 6 ... previous study of random mutations, mostly introduced by error-prone PCR (EPPCR) or DNA shuffling (DS), demonstrated that those closer to the enzyme active site were more effective than ...
2009 JUL 6 ... – Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a ... shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of ...
2009 NOV 23 ... structures. In this study, we constructed chimeras between SOT and SGT using an in vivo DNA shuffling system and several mutants to identify the key residues involved in topological ...
2009 OCT 12 ... and external collaborations and other arrangements. Maxygen uses its proprietary DNA shuffling technology and extensive protein modification expertise to pursue the creation of ...
2009 SEP 7 ... "We recently proposed a DNA replication-based mechanism of fork stalling and template switching (FoSTeS) to explain ... mechanism can explain both the gene duplication-divergence hypothesis(3) and exon shuffling(4), suggesting an important role in both genome and single-gene evolution.." ...
2009 MAR 17 ... Using directed evolution techniques of error-prone polymerase chain reaction (PCR) and DNA shuffling, several Cel5A variants with improved catalytic activity had been screened from the ...
2009 JAN 5 ... disease."
Nakayama and colleagues published their study in DNA Research (The Whole-genome Sequencing of the Obligate Intracellular Bacterium Orientia ... families), many of which are pseudogenes (766 CDSs), and also induced intensive genome shuffling," wrote K. Nakayama and colleagues, Miyazaki University, Medical Department.
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2009 MAY 11 ... United States of America (A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proceedings of the National Academy of Sciences of the United ...
2009 MAY 4 ... therefore, have improved thermal and alkaline stability and are ideal candidates for DNA shuffling experiments to produce a robust xylanase for industrial application."
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2009 SEP 28 ... enzymes that share similar helicase and nuclease activities and initiate repair of DNA double-strand breaks by homologous recombination. Examination of the phylogenetic ... published their study in the Journal of Bacteriology (Phylogenetic Ubiquity and Shuffling of the Bacterial RecBCD and AddAB Recombination Complexes. Journal of Bacteriology, ...
2009 SEP 7 ... According to a study from South Korea, "DNA shuffling was carried out with two chitosanase genes belonging to glycoside hydrolase family eight ...
2009 MAR 9 ... the functionality of lipase from Proteus vulgaris (PVL) we have used error-prone PCR and DNA shuffling methods to create PVL mutants with improved lipase activity. One desirable mutant with ...
2009 NOV 1 ... The method naturally mixes test and training data from site-directed recombination, DNA shuffling, or random mutagenesis experiments. We train a model from a site-directed recombination ...
2009 JUN 29 ... A team of Scripps Research scientists has created a new analog to DNA that assembles and disassembles itself without the need for enzymes. Because the new ... The DNA-DNA pairings remain stable, causing the tPNA components to resume their unstable shuffling until a new DNA template is added and the process begins again.
The ...
2009 AUG 18 ... Vpma phase variation is generated by a cluster of six vpma genes that undergo frequent DNA rearrangements via site-specific recombination." "To further comprehend ... The researchers concluded: "The role of such mobile genetic elements in chromosomal shuffling of genes encoding major surface components may have important evolutionary and ...
2009 MAR 30 ... isolating cellulases with improved activity from a cellulase library created by family DNA shuffling. This application provides further evidence that chemical complementation can be readily ...
2009 SEP 28 ... in the United States report. "Four rounds of random mutagenesis and DNA shuffling of Drosophila melanogaster 2'-deoxynucleoside kinase, followed by FACS analysis, ...
