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2009 OCT 19 ... According to a study from Beijing, People's Republic of China, "Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to ...
2009 NOV 1 ... new enzyme drug discovery kits for histone deacetylases (HDACs) and lysine-specific demethylase 1 (LSD1), emerging targets for cancer and other diseases. Histone ...
2009 OCT 5 ... encoded by JMJD1A (a gene also known as JHDM2A), which has been identified as a histone demethylase that regulates the transcription of androgen receptor targets. We confirm, by RT-PCR, ...
2009 OCT 19 ... these compounds, new triazole derivatives that inhibit the parasite's C14 alpha sterol demethylase are the most promising, as they have been shown to have curative activity in murine ...
2009 AUG 24 ... The mechanism of demethylation, the candidate enzyme(s) exhibiting direct demethylase activity, and associated cofactors are not firmly established. Use of azanucleosides, ...
2009 SEP 8 ... acetyltransferase (Sas2), two histone methytransferases (Dot1 and Set1) and one histone demethylase (Jhd2) to the dynamics of silencing," wrote E.A. Osborne and colleagues, University of ...
2009 SEP 7 ... Investigators publish new data in the report 'Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.' "Histone H3 lysine 9 (H3K9) methylation is a crucial ...
2009 SEP 22 ... of one of the two predicted CYP genes (YP_143162) showed low-level homology to sterol 14-demethylase (CYP51) and contained a C-terminal polypeptide domain of unknown function." ...
2009 NOV 3 ... peptide (PIP) sequence called the PIP box. We have previously shown that the oxidative demethylase human AlkB homologue 2 (hABH2) colocalizes with PCNA in replication foci." ...
2009 NOV 2 ... to acetylated historic H3 on p21(WAF-1) promoter. Interestingly, lysine-specific demethylase-1 (LSD1) silencing reduced both pomalidomide and lenalidomide up-regulation of ...
2009 SEP 21 ... of life-threatening fungal infections in immunocompromised patients. Lanosterol 14 alpha-demethylase (CYP51) is the target of azole antifungal agents," scientists writing in the journal ...
2009 OCT 6 ... lauric acid 12-hydroxylase activity increased at all doses. Decreases in aminopyrine N-demethylase activity and testosterone 2 alpha- and 16 alpha-hydroxylase activity were also found at ...
2009 NOV 9 ... "The mechanisms of resistance involve mutations in the cyp51A (sterol demethylase) gene, and patterns of azole cross-resistance have been linked to specific mutations. ...
2009 AUG 24 ... remains to be addressed. Here, we show that TAL1 is associated with histone demethylase complexes containing lysine-specific demethylase 1 ...
2009 NOV 9 ... to inhibition by antifungal azole drugs that normally target sterol 14 alpha-demethylase (CYP51). Although antifungal azoles show promise, direct screening of compounds against ...
2009 NOV 16 ... mutant human cells in which the F-box leucine-rich protein 11 (FBXL11), a histone H3K36 demethylase, is shown to be a negative regulator of NF kappa B. High levels of FBXL11 block the ...
2009 OCT 12 ... that amine oxidase (flavin-containing) domain 1 (AOF1), a protein related to the lysine demethylase KDM1 (also known as LSD1)(6), functions as a histone H3 lysine 4 (H3K4)...
2009 AUG 24 ... and extensively characterized epigenetic mark. The recent discovery of lysine-specific demethylase 1 (LSD1) demonstrated that lysine methylation can be dynamically controlled." ...
2009 NOV 23 ... lysine-27 (H3K27) methylation; and the latter methylation marks are removed by the H3K27 demethylase Jumonji domain containing 3 (Jmjd3). We found that continuous interleukin-4 (IL-4) ...
