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2009 NOV 9 ... augmentation of the glucoregulatory factor GLP-1 would improve glucose tolerance in diabetic GK rats. We compared two procedures that increase distal small bowel stimulation, ileal ... (Duodenal-Jejunal Exclusion Improves Glucose Tolerance in the Diabetic, Goto-Kakizaki Rat by a GLP-1 Receptor-Mediated Mechanism. Journal of Gastrointestinal Surgery, ...
2009 NOV 9 ... were prepared and administered to healthy female Sprague-Dawley rats and to male Zucker diabetic obese rats." "Rats received a single dose of GLP-1 Technosphere Powder by ... Technosphere ® Inhalation Powder for diabetes therapy has been demonstrated in a rat model. GLP-1 Technosphere Inhalation Powders containing 5, 10 and 15% GLP-1 were ...
2009 NOV 23 ... that antioxidant therapy may restore erectile function by inhibiting apoptosis in diabetic rat crura." "A total of 40 male Sprague-Dawley rats were randomized to 5 ...
2009 NOV 23 ... as a result of enhanced insulin sensitivity during electroacupuncture in spontaneously diabetic Goto-Kakizaki rats. Metabolism - Clinical and Experimental, 2009;58(10):1372-1378). ... (EA) applied oil the abdomen improved glucose tolerance in the Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes mellitus. Male GK rats and nondiabetic Wistar rats ...
2009 NOV 9 ... Fatty (OLETF) rats (type 2 diabetes model) at the early hyperglycaemic stage [vs. non-diabetic Long-Evans Tokushima Otsuka (LETO) rats]." "Experimental approach: ... (Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin. British Journal of Pharmacology, ...
2009 NOV 23 ... the slow deterioration of the functional beta-cell mass in glucose intolerant and type 2 diabetic patients." Jonas and colleagues published their study in Diabetes Obesity ... regulation of oxidative stress-response and integrated stress-response genes in cultured rat islets follows an asymmetric V-shaped profile parallel to that of beta-cell apoptosis, ...
2009 NOV 9 ... "Short term exenatide treatment normalizes the altered vascular tone in type 2 diabetic rats, probably due to the reduction in glycemia. The aim of this study was to ... exenatide directly protects against triglyceride-induced endothelial dysfunction in rat femoral arterial rings ex vivo. Short term pre-incubation with Intralipid ® (0.5 ...
2009 NOV 9 ... transporter 4 (GLUT 4) protein levels were dramatically reduced in both I/R and non-I/R diabetic rat hearts. Insulin treatment in diabetes showed improvement of contractile function as well ...
2009 NOV 23 ... control; group II was treated only with streptozotocin (80 mg/kg i.p.) and served as the diabetic control; groups III and IV were treated with aspirin (70 mg/kg/day p.o.) for 7 and 2 ... to investigate the role of aspirin in preventing type 2 diabetes in ruts. At 5 days old, rat pups were divided into four groups," scientists in Warangal, India report. ...
2009 NOV 16 ... type 2 diabetes. Decreased viability and dysfunction of beta cells would accelerate the diabetic pathogenesis associated with higher mortality." "In this study, the tea ... secretory machinery and stimulate insulin receptor substrate 2 (IRS2) signaling in rat pancreatic beta cells, RIN-m5F. These findings further demonstated the reduced ...
2009 NOV 9 ... mg/kg) was administered five consecutive days in a week for 3 weeks to both control and diabetic rats. Thiobarbituric acid reactive substances (TBARS) levels were measured in the ... of Hyperglycaemia on Chemical-Induced Toxicity: Study with Cyclophosphamide in Rat. Basic & Clinical Pharmacology & Toxicology, 2009;105(4):236-242). For ...
2009 NOV 23 ... renal tubular epithelial cells contributes to the renal fibrosis that is associated with diabetic nephropathy. Histone deacetylase (HDAC) determines the acetylation status of histones ... In streptozotocin (STZ)-induced diabetic kidneys and TGF-beta 1-treated normal rat kidney tubular epithelial cells (NRK52-E), we found that trichostatin A, a nonselective ...
2009 NOV 9 ... According to a study from Dusseldorf, Germany, "The pathophysiology of diabetic retinopathy involves leukocyte adhesion to retinal vasculature, early blood-retinal ... were analyzed in trypsin digest preparations. Endothelial cell injury and apoptosis in rat retinas were evaluated by propidium iodide, TUNEL, CytoDeath staining, and DNA ...
2009 NOV 23 ... is a frequent and severe complication of diabetes. Multiple metabolic defects in type 2 diabetic patients result in oxidative injury of dorsal root ganglia (DRG) neurons," scientists ... We also examined oxidized lipid-mediated injury in cultured DRG neurons from adult rat using oxidized LDLs (oxLDLs). Mice on a high-fat diet have increased oxLDLs and systemic ...
2009 NOV 2 ... anti-inflammatory and anti-apoptotic actions in cardiovascular, hepatic and diabetic disorders." The researchers concluded: "That SF may have beneficial ... effects on OA. Therefore, present study investigated the effects of SF in an in vivo rat OA model, as well as in vitro in human OA chondrocytes. Rats were divided into the ...
2009 NOV 16 ... ADRP protein content was examined during the development of insulin resistance in Zucker diabetic fatty (ZDF) rats and in type 2 diabetes patients and BMI-matched control subjects. ... Endocrinology & Metabolism (Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes ...
2009 NOV 23 ... reactive oxygen species (ROS) and apoptosis in cardiomyocytes, which contributes to diabetic cardiomyopathy. The present study was to investigate the role of Rac1 in ROS production ... and their wild-type littermates by injection of streptozotocin (STZ). In cultured adult rat cardiomyocytes, apoptosis was induced by high glucose. The results showed a mouse model ...
2009 NOV 2 ... inhibitor (IC50 = 0.23 mu g/mL), and may be useful in the prevention and/or treatment of diabetic complications." Lee and colleagues published their study in the Journal of ... "In this study, we conducted pharmacological investigations upon experimental rat lenses using extracts of the fruits of Litchi chinensis (Sapindaceae). Of the extracts ...
2009 NOV 2 ... with 35 mg/kg streptozotocin (STZ) and divided into insulin-treated and untreated diabetic groups." "The rats were studied over 8 months and measurements made of ... is a primary life-threatening complication of long-term diabetes in humans, this rat model of STZ-induced diabetes showed that the rapid onset of physiological ...
