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2009 AUG 24 ... tomography (SPECT) imaging in patients presenting with symptoms or signs suggestive of dopaminergic neurodegeneration. In May 2009, the FDA accepted the New Drug Application and granted DaTSCAN ...
2009 NOV 1 ... regulatory elements. Homozygous R1441C KI mice appear grossly normal and exhibit no dopaminergic (DA) neurodegeneration or alterations in steady-state levels of striatal dopamine up to ...
2009 JUL 27 ... "Parkinson's disease (PD) is a common movement disorder marked by the loss of dopaminergic (DA) neurons in the brain stem and the presence of intraneuronal inclusions designated ... the presence of intraneuronal inclusions designated as Lewy bodies (LB). The cause of neurodegeneration in PD is not clear, but it has been suggested that protein misfolding and aggregation ...
2009 OCT 19 ... analysis demonstrated a PGJ2 dose-dependent significant and selective loss of dopaminergic neurons in the substantia nigra while the GABAergic neurons were spared. PGJ2 also ... cyclooxygenases and their prostaglandin products redirect cellular events to promote PD neurodegeneration. The major prostaglandin in the mammalian brain is prostaglandin D2, which readily ...
2009 NOV 23 ... Researchers detail in 'Progressive dopaminergic degeneration in the chronic MPTPp mouse model of Parkinson's disease,' new data in ... Research report. "The present study investigated the progressive nature of neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTPp) chronic mouse ...
2009 NOV 9 ... evidence of neurodegeneration, such as alpha-syn deposits, compromised function of dopaminergic neurons, fibrillization of alpha-syn, and astrogliosis," scientists in Tokyo, Japan ...
2009 NOV 23 ... does not lead to mitochondrial complex I inhibition as seen in males and the progressive dopaminergic cell loss in substantia nigra (SNpc) is significantly attenuated. Redox driven apoptotic ... pathways regulated by thiol disulfide oxidoreductase(s) have been implicated in the neurodegeneration seen in PD. Oxidation of thioredoxin leads to activation of apoptosis signal regulating ...
2009 OCT 19 ... from the United States, "Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose ...
2009 SEP 28 ... disorder characterised by a progressive loss of the substantia nigra pars compacta (SNc) dopaminergic neurons as well as of the locus coeruleus (LC) noradrenergic neurons. It has been ... Data detailed in 'Effect of the additional noradrenergic neurodegeneration to 6-OHDA-lesioned rats in levodopa-induced dyskinesias and in cognitive disturbances' ...
2009 AUG 24 ... Fresh data on life sciences are presented in the report 'Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after ... be obtained by contacting A.S. Rolland, INSERM, UMR_S975, Experimental Therapeutics of Neurodegeneration, Paris, France. The publisher of the Journal of Neurochemistry can be ...
2009 SEP 28 ... A new study, 'Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line,' is now available. "Reactive oxygen species and oxidative stress are ... conditions. However, the exact molecular mechanisms triggered by oxidative stress in neurodegeneration are still unclear," investigators in Barcelona, Spain report. "This study ...
2009 AUG 24 ... in the pathogenesis of neurodegeneration. In Parkinson's disease (PD) patients, the dopaminergic neurons are subjected to oxidative stress resulting from reduced levels of antioxidant ...
2009 AUG 3 ... their study in the Journal of Molecular Neuroscience (GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum. Journal of Molecular Neuroscience, ...
2009 OCT 19 ... persists long after resolution of the infection. We also observe a significant loss of dopaminergic neurons in the substantia nigra pars compacta 60 days after infection," wrote H.M. Jang ... influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America, ...
2009 SEP 14 ... at day 3 post-lesion when there was no apparent loss of tyrosine hydroxylase (TH)+ve dopaminergic (DA) SNc neurons," wrote L. Marinovamutafchieva and colleagues, University of London, ... Parkinson's disease," scientists in London, the United Kingdom report. "Neurodegeneration in the substantia nigra pars compacta (SNc) was induced by unilateral injection of ...
2009 JUL 20 ... system. However, it remains unclear how loss of Parkin protein causes dopaminergic dysfunction and nigral neurodegeneration." "To investigate the pathogenic ...
2009 JUL 27 ... in brain. Previous studies have shown that ANA reduced neurodegeneration caused by the dopaminergic neurotoxin 6-hydroxydopamine in rat striatum and substantia nigra." "The ...
2009 JUL 20 ... astrocytes and protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration in mice. Furthermore, Oct3 deletion impairs the removal of the excess extracellular ...
2009 JUL 20 ... Researchers detail in 'In-vitro analysis of Pitx3 in mesodiencephalic dopaminergic neuron maturation,' new data in life sciences. "The transcription factor Pitx3 is ... report. "To investigate the connection between Pitx3 and selective neurodegeneration, we generated embryonic stem cells from a Pitx3-deficient mouse (aphakia) for in-vitro ...
