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2009 JAN 5 -- Researchers detail in 'Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy,' new data in enzyme research. "Macroautophagy, a tightly orchestrated intracellular process for bulk......
2009 APR 27 -- According to recent research from the United States, "Clinical trials have shown oncolytic adenoviruses to be tumor selective with minimal toxicity toward normal tissue. The virus ONYX-015, in which the gene encoding the early region 1B 55-kDa......
2009 JUN 29 -- " To evaluate the interexaminer and intraexaminer reliability of macular microperimetry using the microperimeter MP-1. Participants: Fifteen healthy volunteers younger than 40 years of age (Group 1), 15 healthy subjects over 60 years (Group 2),......
2009 NOV 2 -- According to recent research published in the Journal of Virology, "During a productive infection, species C adenovirus reprograms the host cell to promote viral translation at the expense of cellular translation. The E1B 55-kilodalton (E1B-55K)......
2009 JUL 13 -- "The human adenovirus E4orf6 and E1B55K proteins promote viral replication by targeting several cellular proteins for degradation. The E4orf6 product has been shown by our group and others to form an E3 ubiquitin ligase complex that contains......
2009 SEP 14 -- According to recent research published in the journal BMC Cancer, "Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been......
2009 MAR 16 -- A report, 'Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma,' is newly published data in Cancer Science. According to recent research published in the journal......
2009 OCT 19 -- According to recent research from Hamburg, Germany, "The adenovirus type 5 (Ad5) early region 1B 55-kDa (E1B-55K) protein is a multifunctional regulator of cell-cycle-independent virus replication that participates in many processes required for......
2009 APR 13 -- According to a study from the United States, "Myocardial ischemia-reperfusion injury may lead to cardiac dysfunction or death. This study investigates the potential efficacy of a novel thrombin fragment (TP508) on myocardial......
2009 APR 20 -- "Oncolytic virus H101 is an adenovirus with an E1B-55KD gene deletion, which selectively replicates in tumor cells, rather than in normal cells, resulting in specific tumor cytolysis. Taking the selective killing of peritoneally planted tumor......
2009 NOV 2 -- Data detailed in 'The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element' have been presented. According to recent research from Adelaide, Australia, "The......
2009 SEP 21 -- A new study, 'Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect,' is now available. According to recent research from Seoul, Korea, "Radiation therapy, a......
2009 FEB 23 -- According to recent research from the United States, "We constructed an oncolytic adenovirus, Adeno-hTERT-E1A, with deletions of the viral E1B, E3A, and E3B regions and insertion of a human telomerase reverse transcriptase (hTERT)......
2009 OCT 12 -- "PDCD5 (programmed cell death 5) accelerates apoptosis of certain tumor cells and the replication-defective Ad-PDCD5 may be a promising agent for enhancing chemosensitivity. In this study, a triple-regulated conditionally replicating......
2009 MAY 19 -- According to recent research from the United States, "The human adenovirus type 5 (Ad5) E1B 55-kDa protein modulates several cellular processes, including activation of the tumor suppressor p53. Binding of the E1B protein to the activation......
2009 JUN 15 -- "Adenovirus infection induces a cellular DNA damage response that can inhibit viral DNA replication and ligate viral genomes into concatemers. It is not clear if the input virus is sufficient to trigger this response or if viral DNA......
2009 MAR 2 -- According to recent research published in the journal Cancer Gene Therapy, "Combination therapy with replicative oncolytic viruses is a recent topic in innovative cancer therapy, but few studies have examined the efficacy of oncolytic......
2009 NOV 2 -- According to a study from the United States, "Tumor cells harbor unique genetic mutations, which lead to the generation of immunologically foreign antigenic peptide repertoire with the potential to induce individual tumor-specific immune......
