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2009 NOV 2 ... assays. Additionally, Caliper introduced a number of novel assays for epigenetic targets and cytochrome p450 toxicity assays. Speakers at this event ... amazing research being done by our customers using LabChip systems to create life-saving drugs," he said. "We're proud of our close association with senior R&D leadership ...
2009 OCT 19 ... progress a number of these lead programs into proof-of-concept studies." Epigenetic enzymes have been identified for their critical roles in various cancers, and emerging ... Epizyme, Inc., a biopharmaceutical company, was founded in 2007 to create innovative drugs for major diseases based on new discoveries emerging from the field of epigenetics. ...
2009 NOV 29 ... groups."There is an urgent need to try and identify biomarkers, such as epigenetic changes, that indicate increased risk for metabolic diseases and use these to tailor ... which may be in the form of simple lifestyles, nutritional intervention or preventive drugs to reduce the burden of metabolic diseases," added Dr. Kwek, who is also Chairman, ...
Subject: Agency for Science, Technology and Research A*STAR, Singapore
2009 NOV 16 ... set of supported applications, including whole transcriptome profiling and discovery, epigenetic studies, whole genome resequencing, de novo sequencing, targeted resequencing, ... clinical research, allow diseases to be detected earlier, and permit better choices of drugs for individual patients. Keywords: , Health, Biotechnology, Genetics, Other ...
2009 SEP 28 ... The researchers concluded: "These data suggest that inhibition of HDAC is a promising epigenetic therapy for ER-negative human breast cancer." Zhou and colleagues ... United States, Baltimore, Breast Cancer, Breast Carcinoma, Cancer Research, Deacetylase, Drugs, Endocrine, Enzyme Research, Oncology, Therapy, Treatment, Vorinostat, Women's Health, ...
2009 OCT 5 ... methylation, such as imprinted genes, and pseudoautosomal genes, thus pointing to epigenetic dysregulation. These alterations are susceptible to reversal upon homocysteine-lowering ... Keywords: Italy, Naples, Cardiology, Cardiovascular, Cardiovascular Risk, Dialysis, Drugs, Folic Acid, Hyperhomocysteinemia, Kidney Disease, Pharmaceuticals, Therapy, Treatment, ...
2009 SEP 28 ... "Epigenetic changes such as DNA methylation play a key role in the development and progression of ... Keywords: Japan, Sapporo, Bone Marrow, Cancer, Cancer Research, DNA, Dexamethasone, Drugs, Experimental Design, Multiple Myeloma, Myeloma, Oncology, Pharmaceuticals, Therapy, ...
2009 NOV 1 ... apoptosis. In summary, our data characterise a novel molecular mechanism that links the epigenetic regulator HDAC2 to the regulation of the pro-apoptotic BH3-only protein NOXA in PDAC," ... England. Keywords: Germany, Munich, Adenocarcinoma, Apoptosis, Deacetylase, Drugs, Enzyme Research, Enzymes, Enzymology, Etoposide, Gastroenterology, Oncology, Pancreas, ...
2009 NOV 24 ... mechanisms that have been broadly suggested to be involved in these processes are the epigenetic modifications that could 'record' perinatal stimuli," researchers in Santiago, Chile ... City:Santiago, Country:Chile, City:Santiago, Country:Chile, Life Sciences, Pharmacology, Drugs, Pharmaceuticals, Therapy, Treatment, Genetics, DNA, Angiology, Endothelium, Physiology, ...
2009 SEP 28 ... "Epigenetic silencing of essential components of DNA repair pathways is a common event in many tumor ... of the affected repair pathways that, when inactivated, sensitize the tumors to specific drugs and are thus exploitable for individualized therapy. (Clin Cancer Res ...
2009 NOV 1 ... needed for induction of progesterone target genes and acetylates histone H3 at K14, an epigenetic mark that interacts with the BAF subunits by anchoring the complex to chromatin. In the ... CA 94107, USA. Keywords: Spain, Barcelona, Breast Cancer, Breast Carcinoma, Drugs, Hormones, Oncology, Pharmaceuticals, Progesterone, Therapy, Treatment, Women's Health. ...
2009 OCT 19 ... by CYP1A2 has been observed, which is largely caused by genetic (e.g., SNPs) and epigenetic (e.g., DNA methylation) and environmental factors (e.g., smoking and comedication). ... one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens ...
2009 NOV 16 ... tumor biopsies and peripheral blood mononuclear cells (PBMC) were analyzed to evaluate epigenetic changes in response to therapy. EBV titers were evaluated as a surrogate measure for ... solid tumors, and toxicity was recorded. The pharmacokinetics of the combination of drugs was evaluated. Repeat tumor biopsies and peripheral blood mononuclear cells (PBMC) were ...
2009 NOV 2 ... what is known as epigenetics - inherited changes in gene regulation. "The epigenetic link to autism is extremely exciting as it provides another opportunity for us to ... with other clinical tests for diagnosing autism. Gregory said that methylation-modifying drugs also may be a new avenue for treatments. Though not a change to the DNA ...
2009 OCT 19 ... in Tokyo, for his outstanding and innovative research in basic science in the "epigenetic field for cancerization". The ceremony took place on October 3rd, during the General ... biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, and the Japanese Cancer Association (JCA) presented ...
