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2009 NOV 16 ... product candidate discovery company. Unlike traditional high throughput trial and error experimental based discovery, Compugen's discovery efforts are based on in silico (by computer) ... Coma, Diagnostics, Drug Development, Eclampsia, Endothelium, Genetics, Genomics, Hypertension, Marketing and Licensing Agreements, Nephrology, Obstetrics, Pharmaceuticals, ...
2009 NOV 16 ... discomfort." Ushio and colleagues published their study in Clinical and Experimental Nephrology (Utility and feasibility of a new programmable home blood pressure monitoring ... of office blood pressure for evaluating cardiovascular risks in subjects with hypertension. The major advantage of ABPM over HBPM is the ability to measure nighttime blood ...
2009 NOV 16 ... Sasatomi and colleagues published the results of their research in Clinical and Experimental Nephrology (Anemia and hypertension are risk factors for both renal prognosis and ...
2009 NOV 23 ... over a mean of 7.8 years," scientists writing in the journal Metabolism - Clinical and Experimental report. "High-density lipoprotein cholesterol levels were found to be ... in logistic regression analyses for age, smoking status, physical activity grade, hypertension, abdominal obesity, diabetes, and lipid-lowering drugs. However, men were not protected ...
2009 NOV 23 ... Inc. (OTC Bulletin Board: PLMO.OB; Frankfort Borse: PBO) has announced that early experimental results have indicated that its PulmoBind™ product candidate can be potentially ... mainly concentrated on the use of PulmoBind™ as a diagnostic agent for Pulmonary Hypertension (PH) and Pulmonary Embolism (PE). While our work in these areas continues, early ...
2009 NOV 23 ... in PAH." Kugathasan and colleagues published their study in the Journal of Experimental Medicine (The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary ... role of the angiopoietin-1 (Ang1)-Tie2 pathway in the pathogenesis of pulmonary arterial hypertension (PAH) is controversial. Although Ang1 is well known to prevent endothelial activation ...
2009 NOV 16 ... tested the hypothesis that MCPs regulate cardiac microvascular function and structure in experimental HTN. Pigs (n=6 per group) were studied after 10 weeks of normal, renovascular HTN, or ... proteins (MCPs) play an important role in mediating inflammatory processes. Hypertension (HTN) is associated with inflammation as well as impaired cardiac microcirculatory ...
2009 NOV 16 ... BP fall." Takeda and colleagues published their study in Clinical and Experimental Nephrology (Bedtime administration of long-acting antihypertensive drugs restores normal ... blood pressure (BP) and restores normal nocturnal dipping in nondippers with essential hypertension," researchers in Kutsukake, Japan report. "We studied 71 Japanese ...
2009 NOV 17 ... The researchers concluded: "We provide mechanistic understanding and experimental in vitro support for the benefit of combination therapy with dual blockade of AT(1)R and ... for the benefit of combination therapy with dual blockade of AT(1)R and MR to treat hypertension and progression of heart failure as reported in clinical studies and animal models. ...
2009 NOV 23 ... of L-arginine in the course of ischemia and reperfusion syndrome after acute, experimental ischemia of the hind legs of the rat, could influence nitric oxide (NO) concentration ... P. Bogdanski, University of Med Science, Dept. of Internal Medicine Metab Disorders & Hypertension, Poznan, Poland. The publisher's contact information for the International ...
2009 NOV 23 ... Sahin and colleagues published their study in Methods and Findings in Experimental and Clinical Pharmacology (THE DUAL EFFECTS OF LEPTIN ON AORTIC RINGS WITH AND WITHOUT ... "The contractile effect of leptin on basal tone may contribute to the development of hypertension in diabetes." Sahin and colleagues published their study in Methods and ...
2009 NOV 16 ... potentially contributing to HF high morbidity, mortality and economic cost. The Experimental Prospective Study on the Effectiveness and Efficiency of the Implementation of Clinical ... and 13.9%, respectively. Adjusting for age, smoking, New York Heart Association score, hypertension and source of referral, patients in the CP group, as compared to controls, had a ...
2009 NOV 23 ... According to recent research published in the journal Metabolism - Clinical and Experimental, "Melanocortin 3 receptor (MC3-R) has high affinity and specificity to gamma ... to dietary salt may contribute to salt retention and BP elevation in salt-sensitive hypertension. We examined renal MC3-R expression, plasma gamma MSH concentration, and response to ...
2009 NOV 23 ... (microneurography)," scientists writing in the journal Metabolism - Clinical and Experimental report. "The muscle and skin nerve traffic measurements were obtained in a ... ages. Muscle sympathetic nerve traffic values were significantly higher in subjects with hypertension and in those with obesity than in controls (51.2 +/- 2.8 and 52.0 +/- 3.0 vs 37.2 +/- ...
2009 NOV 23 ... preeclampsia (PE), affect similar to 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development ... "Using a deoxycorticosterone acetate (DOCA)/salt-low renin rat model, which exhibits hypertension, proteinuria, endothelial dysfunction, and intrauterine growth restriction (IUGR), we ...
2009 NOV 16 ... conceptual framework to connect circadian and circannual rhythms, sleep and metabolism. Experimental studies have shown sleep deprivation to decrease leptin, increase ghrelin, increase ... sleep duration and increases in metabolic disorders such as obesity, diabetes and hypertension. There is growing evidence that these trends are mechanistically related." ...
2009 NOV 10 ... O2 or reduced oxygen (1-2% O2) conditions. GCM1 protein was not detected in any of the experimental conditions used. This study has shown that acute hypoxia increases GCM-1 protein in ... of preeclampsia." McCaig and colleagues published their study in Hypertension In Pregnancy (Hypoxia upregulates GCM1 in human placenta explants. Hypertension In ...
2009 NOV 10 ... For additional information, contact G.P. Rossi, University Hospital, Dept. of Clinic & Experimental Medical, Clinic Med 4, Via Giustiniani 2, I-35126 Padua, Italy. The ... vein should be undertaken to determine the lateralization of aldosterone secretion. (Hypertension. 2009; 54:885-889.)." Miotto and colleagues published their study in ...
