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2009 NOV 23 ... encoding enzymes of fat synthesis in adipose tissue (acetyl CoA carboxylase (ACACA), fatty acid synthase and stearoyl CoA desaturase (SCD)) and the large differences in expression of lipogenic ...
2009 NOV 27 ... researchers concluded: "Based on the findings, we conclude that the fattyacid composition of mature CL in yeast is governed by the substrate specificity of the ... than C16 in CL. Experiments in which the substrate specificity of the yeast cardiolipin synthase Crd1p and the acyl chain composition of individual short CL species were investigated, ...
2009 NOV 27 ... phosphatidylcholine molecular species containing stearate paired with a polyunsaturated fattyacid to PtdSer. There was no evidence for fattyacid remodeling of PtdEtn. The ... PtdEtn synthesis. PtdSer structure was controlled by the substrate specificity of PtdSer synthase that selectively converted phosphatidylcholine molecular species containing stearate ...
2009 NOV 1 ... and its precursors are needed to improve the uniformly poor prognosis of this disease. Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids and is overexpressed in most ...
2009 NOV 16 ... signaling leads to insulin-regulated metabolism and cardiovascular dyfunctions. Free fatty acids (FFAs) in the circulation are increased in this disorder and inhibit insulin ... the inhibitory effect of palmitate. Taken together, we have demonstrated that palmitic acid induces accumulation of ceramide, which appears to mediate palmitic acid's inhibitory ... the insulin signaling pathway that leads to the activation of endothelial nitric oxide synthase (eNOS) and increase in nitric oxide (NO) production in endothelial cells. Here we ...
2009 NOV 9 ... According to recent research from Rome, Italy, "To evaluate the expression of fatty acid synthase (FAS) in the oesophagitis-Barrett's oesophagus-oesophageal adenocarcinoma sequence ...
2009 NOV 23 ... increased expression of genes for adipogenesis and de novo lipogenesis, increased fatty acid synthase activity, increased proportion of saturated fatty acids in triglyceride (storage) ...
2009 NOV 2 ... by WA supplementation. Supplementation with WA increased the mRNA levels of not only fatty acid synthase (FAS) and acyl-CoA carboxylase (ACC) but also their transcriptional factors such as ...
2009 NOV 23 ... compared with obese controls. The hepatic TG concentration and the relative abundance of fatty acid synthase and acetyl-CoA carboxylase proteins were all lower (P < 0.05) in the VA-treated group ...
2009 NOV 2 ... "The Val1483Ile polymorphism in the human fatty acid synthase (FASN) gene is located within the interdomain region of the FASN close to the two ...
2009 NOV 9 ... research from the United States, "It has been shown that lipogenic enzymes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), are highly expressed in the rodent brain during ...
2009 NOV 16 ... According to a study from Seoul, South Korea, "Arachidonic acid (AA, a proinflammatory fattyacid) in combination with iron promotes excess reactive oxygen species (ROS) production ... or compound C treatment. Resveratrol increased inhibitory phosphorylation of glycogen synthase kinase-3 beta (GSK3 beta) downstream of AMPK, which contributed to mitochondrial ...
2009 NOV 2 ... physical activity assessments after colon cancer diagnosis, we examined expression of fatty acid synthase, p53, p21, and p27 and mutational status of K-ras and phosphatidylinositol ...
2009 NOV 16 ... (35% at the highest dose) and glycolysis rates. Similarly, the reduction of plasma free fattyacid concentrations by insulin was dramatically improved. Basal hepatic glucose ... homeostasis and was associated with an increased content of muscle phospho-Akt, glycogen synthase kinase-3 beta, and AMP-activated kinase. Second, HFD mice were chronically treated with ...
2009 NOV 2 ... pathogenesis of liver disorders. We sought to explore its possible role in non-alcoholic fatty liver disease (NAFLD)." "Serum levels of activin A and its natural ... metalloproteinase activity, induced mitochondrial beta-oxidation, downregulated fatty acid (FA) synthase activity, promoted decreased weight percentage of saturated FAs, and ...
2009 NOV 9 ... GABAeric system and the modulation of food intake. Furthermore, the upregulation of fattyacid-binding protein 4 and the downregulation of 78 kDa glucose-regulated protein in the ... of hypothalamic voltage-dependent anion-selective channel protein 1 and fat ATP synthase suggested a reduction in synthesis of mitochondrial ATP," wrote A. Mishra and ...
