Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Google 2009 PageRank: #2 Among Top Health News and Media Publications
Google 2009 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2009 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2009 PageRank: #2 News and Media Site for the Pharmaceutical Industry
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
2009 SEP 7 ... peptides, generated by the proteolysis of beta-amyloid precursor protein by beta- and gamma-secretases, play an important role in the pathogenesis of Alzheimer disease. ... suppressed EP4, but not EP2, receptor-mediated stimulation. Activation of gamma-secretase was observed with the activation of EP4 receptors but not EP2 receptors. ...
2009 NOV 23 ... nicastrin, anterior pharynx defective-1 and presenilin enhancer-2, constitutes gamma-secretase, which is required for the generation of amyloid beta-protein. In this ...
2009 NOV 16 ... an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells." ...
2009 NOV 2 ... Abeta levels,' are detailed in a study published in Journal of Neurochemistry. "Gamma-secretase modulators (GSMs) include selected non-steroidal anti-inflammatory drugs such ...
2009 NOV 23 ... development of familial Alzheimer disease, is an important functional component of the gamma-secretase complex that processes many cell surface receptors including the EphB2 ...
2009 SEP 14 ... as a stable high-molecular-weight protein complex, together with other components of gamma-secretase." "However, as there has been no report about the precise ...
2009 SEP 7 ... "Eli Lilly & Co is developing semagacestat, an inhibitor of the gamma-secretase enzyme. This enzyme is pivotal in the generation of beta-amyloid (A beta), a ...
2009 AUG 31 ... both VSMC and macrophages. In cultured VSMC, CD74 expression was induced by interferon gamma (IFN gamma). Incubation with an agonistic anti-CD74 antibody or with IFN gamma elicited ... or with IFN gamma elicited MCP-1 expression, which was prevented by AKT and gamma-secretase inhibitors. Moreover, CD74 small-interfering RNA decreased NF-kappa B activation and ...
2009 SEP 7 ... cleavage of amyloid precursor protein (APP) by a family of protease, alpha-, beta-, and gamma-secretase. Sub W, a substrate peptide, consists of 10 amino acids, which are adjacent to ...
2009 NOV 9 ... targeting the NOTCH signaling pathway in this disease." "Small-molecule gamma-secretase inhibitors (GSIs), which block a critical proteolytic step required for NOTCH1 ...
2009 NOV 1 ... derived from the beta-amyloid precursor protein (APP) by the enzymes alpha-, beta- and gamma-secretase," scientists in South Korea report. "Compounds that enhance ...
2009 SEP 28 ... CNS." "The objective of this study was to determine the effects of a gamma-secretase inhibitor on the production of A beta in the human CNS. We utilized a recently ...
2009 SEP 14 ... known be involved in amyloidogenesis, Src and CDK5, and associated with alpha and gamma secretase-mediated p75 processing." "Pharmacologic inhibition of TrkA ...
2009 AUG 24 ... Scientists discuss in 'Dietary deficiency increases presenilin expression, gamma-secretase activity, and Abeta levels: potentiation by ApoE genotype and alleviation by ...
2009 OCT 12 ... treatment of familial Alzheimer's disease. Unfortunately, many inhibitors that block gamma-secretase-mediated cleavage of APP also have immunosuppressive side effects." ...
2009 NOV 11 ... and the expression of some NF-kappa B family members. Treatment of macrophages with the gamma-secretase inhibitor DAPT, which prevents the cleavage and activation of Notch receptors, ...
2009 OCT 5 ... According to recent research from the United States, "1. BMS-299897 is a gamma-secretase inhibitor that was effective in reducing amyloid beta-peptide (A beta) in ...
