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2009 NOV 16 ... cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a ...
2009 NOV 16 ... in the Mexican cohort. Furthermore, 17 of the 23 novel associations involved HLA alleles whose frequencies were not significantly different from those in IHAC, suggesting that ...
2009 NOV 2 ... and Rheumatism (Reevaluation of the Interaction Between HLA-DRB1 Shared Epitope Alleles, PTPN22, and Smoking in Determining Susceptibility to Autoantibody-Positive and ...
2009 NOV 23 ... assay. In the initial analysis of unrelated case-control samples, three DNASE2 SNP alleles in the 5'-regulatory region were significantly more frequent in patients with RA than ...
2009 NOV 10 ... that US6 has differential effects on the cell-surface expression of MHC class I alleles and are consistent with TAP being the sole inhibitory target of US6 in the MHC class I ...
2009 NOV 23 ... and low body mass index (BMI). In separate modeling that included HLA genes, HLA alleles DRB1*0802 and DQA1*0501 were significant predictors of mortality in addition to the ...
2009 NOV 2 ... a proportion comparable with rheumatoid factor, and greater than HLA-DRB1 shared epitope alleles or C-reactive protein levels. Resistin and leptin were not associated with radiographic ...
2009 NOV 1 ... in Linz, Austria report. "This study evaluates the impact of HLA-E alleles on transplantation outcome after HLA-matched allogeneic HSCT. We genotyped DNA for HLA-E ...
2009 NOV 9 ... system to analyze chimeric mixtures is demonstrated here by the detection of a rare HLA-B allele in a mixture of two homozygous cell lines (1/100), as well as by the detection of ... donors for recipient patients." "In current methods for HLA typing, both alleles of a heterozygote are amplified and typed or sequenced simultaneously, often making it ...
2009 NOV 3 ... single-nucleotide polymorphisms (SNPs) were genotyped and the transmission of alleles in nuclear families was analyzed using the FBAT (family-based association test). To ...
2009 NOV 16 ... "Susceptibility to celiac disease (CD) is related to HLA-DQ2 and DQ8 alleles and the heterodimers they encode. The objective of this study was to stratify risk For ...
2009 NOV 23 ... chain reaction. Peptides were also tested by binding assay against different class II alleles. Peptide PAP(173-192) was recognized more frequently by CD4 T cells from patients with ...
2009 NOV 23 ... a control study. Anti-CCP Abs and HLA-DRB1 typing were determined for all subjects. The alleles most strongly associated with RA were HLA-DRB1 [*01, *04 and *06] (41.4%). RA patients ...
2009 NOV 2 ... and 5 group-specific PCR reactions were carried out to determine all of the other HLA-B alleles. Clinical manifestations of AS and BASH were also evaluated according to homozygosity or ...
2009 NOV 2 ... (P = 0.03) and was more likely to occur within epitopes presented by relevant HLA alleles (P < 0.001)," wrote C. Shiu and colleagues, Johns Hopkins University, Medical ...
2009 NOV 9 ... genotyping is also critically important for research on many human diseases. "Specific alleles and haplotypes at the class I and class II loci are strongly associated with a variety ...
2009 NOV 2 ... patients compared with normal subjects. Compared with CT60, the frequencies of the G alleles and G/G genotypes at the A/G(49) were more significantly higher in patients with ...
2009 NOV 9 ... and numbers of copies, respectively). Similarly, patients carrying 2 IFNG 13-CA-repeat alleles (homozygotes) had more frequent CMV reactivation (0.50 vs 0.26; P = .039) and a higher ...
2009 NOV 9 ... of CD with virtually all individuals that develop the disease carrying HLA-DQ alleles that encode specific HLA-DQ2 or HLA-DQ8 heterodimers," investigators in Tokyo, Japan ...
2009 NOV 3 ... is conferred by SE." "We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone. We analysed data ...
