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2009 NOV 30 ... myeloid malignancies. In mice, expression of oncogenic K-RAS or inactivation of Nf1 in hematopoietic cells results in myeloproliferative disorders (MPDs) that do not progress to acute myeloid ...
2009 NOV 30 ... Fate Therapeutics is developing its lead Stem Cell Modulator, FT1050, to enhance hematopoietic stem cell (HSC) proliferation and homing. The small molecule is currently undergoing ... Paul Grayson, president and CEO of Fate Therapeutics. "Target populations of adult stem cells must be exquisitely characterized and quantitated, and we are employing genomic, ...
2009 NOV 30 ... WT1 mRNA is overexpressed in the minimal residual disease (MRD) of patients with hematopoietic malignancy patients, particularly acute myeloid leukemia (AML)." "MRD ... (AML)." "MRD represents the condition with the low levels of leukemia cells in the bone marrow and is known as a sign of recurrence. In hematopoietic malignancies, ...
2009 NOV 30 ... phosphorylated nuclear factor kappa B (NF kappa B). When osteoclasts prepared from mouse hematopoietic stem cells were treated with diclofenac, tartrate-resistant acid phosphatase-positive ...
2009 NOV 30 ... to a study from Vancouver, Canada, "The sialomucin CD43 is highly expressed on most hematopoietic cells. In this study, we show that the CD43 ectodomain is shed from murine granulocytes, mast ...
2009 NOV 23 ... persisted in the transplanted bone at significantly higher levels compared with other hematopoietic compartments. The compartment donor chimerism may be responsible for the maintenance of ... irradiation (TBI, day-1), and 100 X 10(6) T-cell-depleted ACI (RT1A(abl)) bone marrow cells were transplanted oil day 0, followed by a 11-day course of tacrolimus and one dose of ...
2009 NOV 23 ... show that inhibition of HDAC activity leads to surface expression of Hsp70 on various hematopoietic cancer cells, an occurance that was not observed on naive or activated peripheral blood ...
2009 NOV 30 ... "Because HLA-class II is under noninflammatory conditions predominantly expressed on hematopoietic cells, CD4(+) T cells administered late after alloSCT may selectively confer GVL without GVHD. ...
2009 NOV 23 ... bone marrow transplantation (allo-BMT). Using chimeric recipients with NOD2(-/-) hematopoietic cells, we demonstrate that NOD2 deficiency in host...
2009 NOV 23 ... malignancies, but either is not expressed or is expressed at only low levels in normal hematopoietic cells, making it a target for cancer therapy. PRAME is a tumor-associated antigen and has been ...
2009 NOV 30 ... According to recent research from the United States, "Hematopoietic stem cell (HSC) engraftment is a multistep process involving HSC homing to bone marrow, ... homing to bone marrow, self-renewal, proliferation, and differentiation to mature blood cells. Here, we show that loss of p190-B RhoGTPase activating protein, a negative regulator of ...
2009 NOV 30 ... "The bone marrow harbors multipotent mesenchymal stromal cells (MSCs) that nurture hematopoietic stem cells (HSCs). The extracellular matrix (ECM) is an integral part of the bone ...
2009 NOV 23 ... by dynamic magnetic resonance imaging (MRI). In addition, the size of the MSCP in the hematopoietic and mesenchymal compartments was determined, and marrow mononuclear cells expressing ...
2009 NOV 30 ... transporter encoded by the ABCD1 gene. ALD progression can be halted by allogeneic hematopoietic cell transplantation (HCT)." "We initiated a gene therapy trial in two ... trial in two ALD patients for whom there were no matched donors. Autologous CD34(+) cells were removed from the patients, genetically corrected ex vivo with a lentiviral vector ...
2009 NOV 30 ... cells. However, its functions in other cells - including osteoclasts, which are of hematopoietic origin and other cellular processes remain unknown." "Here we report an ...
2009 NOV 28 ... Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical ...
Subject: Cincinnati Children's Hospital Medical Center
2009 NOV 23 ... suggesting a critical relationship between cell motility and tumor relapse in hematopoietic malignancies." Meacham and colleagues published their study in Nature ... a library of shRNAs into individual mice using transplantable E mu-myc lymphoma cells. This approach has allowed us to screen nearly 1,000 genetic alterations in the context ...
2009 NOV 23 ... about the effect of heavy ion beams on the proliferation and differentiation of human hematopoietic stem/progenitor cells (HSPCs)," scientists writing in the Journal of Radiation Research ...
2009 NOV 23 ... versus tumor (GVT) immunotherapy to NB as compared to syngeneic (autologous) immuno-hematopoietic reconstitution. (3) An effective GVT reaction in tumor bearing mice is primed by MHC ... writing in the journal Cancer Immunology Immunotherapy report. "Neuro-2a cells were found to express low levels of class I major histocompatibility complex (MHC) ...
2009 NOV 30 ... "Emerging evidence indicates that p53 plays an important role in regulating hematopoietic stem cell (HSC) quiescence, self-renewal, apoptosis and aging. The p53 pathway is ... development of therapeutic strategies for eliminating leukemia (and cancer) propagating cells." Liu and colleagues published their study in Cell Cycle (The p53 tumor ...
