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2009 APR 13 ... sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells."
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2009 APR 13 ... of multiple myeloma interaction with bone marrow stromal cell and endothelium, including heparanase, angiogenic cytokines, and adhesion molecules. Defibrotide's in vivo chemosensitizing ...
2009 APR 6 ... with both the up-regulation and the increased secretion of several proteases and heparanase."
"In the present study, we tried to determine whether the ...
2009 JUL 13 ... trial investigated the safety, optimal dosage and preliminary efficacy of PI-88, a novel heparanase inhibitor, in the setting of post-operative recurrence of HCC according to a Simon's ...
2009 MAR 9 ... survival and more so when the tumor concurrently expressed high levels of p53, TUNEL and heparanase markers, dramatically dropping the patient survival probability to 0! While no patient ...
2009 NOV 23 ... such as exostosin-1 and -2 or N-deacetylase N-sulfotransferases remained unchanged, but heparanase mRNA and protein expressions in Huh7 cells were decreased upon GAG mimetic treatment. ...
2009 APR 20 ... According to recent research from Haifa, Israel, "Heparanase is an endoglycosidase that degrades heparan sulfate (HS) at the cell surface and in the ...
2009 OCT 5 ... According to a study from Tel Hashomer, Israel, "Heparanase is an endo-beta-glucuronidase that specifically cleaves the saccharide chains of heparan ...
2009 APR 20 ... According to a study from Haifa, Israel, "Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate, activity that is ...
2009 MAY 12 ... in histone variant distribution that accompany activation of the inducible CD69 and heparanase genes in T cells. We demonstrate that the chromatin accessibility increases that ...
2009 SEP 14 ... hypotheses and NMR approaches is reported for the identification of novel inhibitors of heparanase, a key enzyme involved in tumor metastasis through the remodeling of the subepithelial ...
2009 MAR 30 ... and enzymes for ensuring sufficient oxygen supply. One of the overexpressed enzymes is heparanase, an endoglucuronidase that selectively cleaves heparan sulfate (HS) and is implicated in ...
2009 JUL 6 ... Puthanveetil P, Kewalramani G, Deppe S, Ghosh S, Abrahani A, Rodrigues B. Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid. Am J ...
2009 NOV 9 ... several biological molecules, including soluble factors secreted by tumor cells, such as heparanase (HPSE). HPSE is an endo-beta-D-glucuronidase that cleaves heparan sulphate ...
2009 SEP 21 ... on cell migration using a Chinese hamster ovary (CHO) cell line stably over-expressing heparanase. A retrovirus infection system was used to establish a CHO-K1 cell line stably ...
2009 OCT 5 ... healthy rats served as controls (n = 6)." "After 18 weeks, renal heparanase and heparan sulfate (HS) expression were examined by immunofluorescence staining. In ...
2009 AUG 31 ... aim of this study was to screen and identify novel B cell epitopes within the human heparanase protein and to investigate the impact of self-developed anti...
